Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.
Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.
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DOI：
10.1590/0074-02760230069
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发表时间：
2023
影响因子：
2.8
通讯作者：
Brasil, Patricia
中科院分区：
文献类型：
--
作者：
Espindola, Otavio;Resende, Paola C.;Guaraldo, Lusiele;Calvet, Guilherme Amaral;Fuller, Trevon L.;Penetra, Stephanie Lema Suarez;Santos, Heloisa Ferreira Pinto;Pina-Costa, Anielle;da Silva, Michele Fernanda Borges;Moraes, Isabella Campos Vargas;Medeiros, Fernando;Whitworth, Jimmy;Smith, Christopher;Nielsen-Saines, Karin;Siqueira, Marilda M.;Brasil, Patricia
人们对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染后持续存在的非特异性症状感兴趣，被称为2019年长冠状病毒病（Long COVID-19）。目前尚不清楚长期COVID-19的风险是否与先前存在的合并症或初始COVID-19的严重程度有关，包括由于2023年占主导地位的新Omicron谱系引起的感染。 本病例报告的目的是描述急性XBB.1.5感染后长期COVID-19的临床特征。 我们跟踪了一位73岁的里约热内卢女性居民，她在急性感染期间和随后的几个月里被实验室确诊为SARS-CoV-2。通过基因组测序确定SARS-CoV-2谱系。 参与者否认合并症，并在SARS-CoV-2感染前8个月完成了两剂疫苗接种计划，随后进行了两次加强接种。通过病毒谱系XBB.1.5的原发性感染。临床上轻度，但参与者随后报告持续疲劳。 这一病例表明，在完全接种疫苗和加强免疫的无合并症个体中，即使在SARS-CoV-2引起的轻度疾病后，也可能发生Long COVID-19。需要继续监测新的SARS-CoV-2谱系和相关的临床结果。应继续实施预防感染的措施，包括开发有效对抗新变异的新疫苗和抗病毒药物。
There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants.
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影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.1016/j.jcv.2023.105500
发表时间：
2023-08
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Klein EY;Fall A;Norton JM;Eldesouki RE;Abdullah O;Han L;Yunker M;Mostafa HH
通讯作者：
Mostafa HH
DOI：
10.1016/s1473-3099(21)00703-9
发表时间：
2022-04
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Soriano JB;Murthy S;Marshall JC;Relan P;Diaz JV;WHO Clinical Case Definition Working Group on Post-COVID-19 Condition
通讯作者：
WHO Clinical Case Definition Working Group on Post-COVID-19 Condition
影响因子：
33.9
作者：
Ma, Kevin C.;Shirk, Philip;Lambrou, Anastasia S.;Hassell, Norman;Zheng, Xiao-yu;Payne, Amanda B.;Ali, Akilah R.;Batra, Dhwani;Caravas, Jason;Chau, Reina;Cook, Peter W.;Howard, Dakota;Kovacs, Nicholas A.;Lacek, Kristine A.;Lee, Justin S.;MacCannell, Duncan R.;Malapati, Lakshmi;Mathew, Sandra;Mittal, Neha;Nagilla, Roopa R.;Parikh, Rishika;Paul, Prabasaj;Rambo-Martin, Benjamin L.;Shepard, Samuel S.;Sheth, Mili;Wentworth, David E.;Winn, Amber;Hall, Aron J.;Silk, Benjamin J.;Thornburg, Natalie;Kondor, Rebecca;Scobie, Heather M.;Paden, Clinton R.
通讯作者：
Paden, Clinton R.
影响因子：
120.7
作者：
Thaweethai, Tanayott;Jolley, Sarah E.;Foulkes, Andrea S.
通讯作者：
Foulkes, Andrea S.