Levels of selected carcinogens and toxicants in vapour from electronic cigarettes.
Levels of selected carcinogens and toxicants in vapour from electronic cigarettes.
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DOI：
10.1136/tobaccocontrol-2012-050859
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发表时间：
2014-03
期刊：
影响因子：
5.2
通讯作者：
Benowitz N
中科院分区：
文献类型：
--
作者：
Goniewicz ML;Knysak J;Gawron M;Kosmider L;Sobczak A;Kurek J;Prokopowicz A;Jablonska-Czapla M;Rosik-Dulewska C;Havel C;Jacob P 3rd;Benowitz N
电子烟，也被称为电子烟，是一种模仿普通香烟的装置，通过吸入而不燃烧烟草来释放尼古丁。据称，它们不含其他有毒物质，提供尼古丁，是普通香烟的更安全替代品。然而，很少进行毒性测试来评估电子烟产生的蒸汽的化学性质。这项研究的目的是筛选电子烟蒸汽中四组潜在有毒和致癌化合物的含量：羰基、挥发性有机化合物、亚硝胺和重金属。在控制条件下，使用改进的吸烟机，从12个品牌的电子烟和参考产品（药用尼古丁吸入器）产生蒸汽。将选定的有毒化合物从气相中提取到固相或液相中，用色谱和光谱学方法进行分析。我们发现电子烟蒸气中含有一些有毒物质。这些有毒物质的含量比香烟烟雾中的含量低9至450倍，在许多情况下与参考产品中的微量含量相当。我们的研究结果与用电子烟代替卷烟可能大大减少接触特定烟草有毒物质的想法一致。在不愿戒烟的吸烟者中，电子烟作为一种减少危害的策略值得进一步研究。
Electronic cigarettes, also known as e-cigarettes, are devices designed to imitate regular cigarettes and deliver nicotine via inhalation without combusting tobacco. They are purported to deliver nicotine without other toxicants and to be safer alternative to regular cigarettes. However, little toxicity testing has been performed to evaluate the chemical nature of vapor generated from e-cigarettes. The aim of this study was to screen e-cigarette vapors for content of four groups of potentially toxic and carcinogenic compounds: carbonyls, volatile organic compounds, nitrosamines, and heavy metals. Vapors were generated from 12 brands of e-cigarettes and the reference product, the medicinal nicotine inhaler, in controlled conditions using a modified smoking machine. The selected toxic compounds were extracted from vapors into a solid or liquid phase and analyzed with chromatographic and spectroscopy methods. We found that the e-cigarette vapors contained some toxic substances. The levels of the toxicants were 9 to 450 times lower than in cigarette smoke and were, in many cases, comparable to trace amounts found in the reference product. Our findings are consistent with the idea that substituting tobacco cigarettes with electronic cigarettes may substantially reduce exposure to selected tobacco-specific toxicants. E-cigarettes as a harm reduction strategy among smokers unwilling to quit warrants further study.
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影响因子：
5.2
作者：
Bullen, C.;McRobbie, H.;Laugesen, M.
通讯作者：
Laugesen, M.
影响因子：
4.7
作者：
Goniewicz, Maciej L.;Kuma, Tomasz;Kosmider, Leon
通讯作者：
Kosmider, Leon
影响因子：
5.8
作者：
Schripp, T.;Markewitz, D.;Salthammer, T.
通讯作者：
Salthammer, T.
影响因子：
6
作者：
ANTAL, MJ;MOK, WSL;ANDERSON, DGM
通讯作者：
ANDERSON, DGM
影响因子：
3.8
作者：
Cahn, Zachary;Siegel, Michael
通讯作者：
Siegel, Michael