A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis.
A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis.
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p63 (rs17506395) 的遗传变异与乳腺癌易感性和预后相关。
DOI：
10.1016/j.gene.2013.11.038
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发表时间：
2014-02
期刊：
影响因子：
3.5
通讯作者：
Yang, Qifeng
中科院分区：
文献类型：
--
作者：
Jiang, Liyu;Ma, Tingting;Hu, Wenwei;Yang, Qifeng
研究背景P63与P53同源，已被研究参与肿瘤发生和肿瘤进展的多个方面。最近，我们在p63中发现了一个功能性单核苷酸多态(SNP)rs17506395(T>；G)，它与女性生殖和卵巢癌的发生有关。为探讨rs17506395基因多态性与乳腺癌易感性、临床病理特征及预后的关系，采用TaqMan法对rs17506395基因多态性进行分型。用定量逆转录聚合酶链式反应(qRT-PCR)检测p63基因的表达。应用非条件Logistic回归和单因素Cox风险回归分析rs17506395与乳腺癌易感性和预后的关系。结果首先，我们发现TT型乳腺癌组织中p63基因的表达水平高于其他基因型，提示rs17506395在乳腺癌中可能是一个功能性单核苷酸多态。进一步的研究发现，与含有G等位基因的基因型(GG和GT)相比，TT基因的存在与乳腺癌风险的增加在统计学上是相关的。此外，还观察到rs17506395基因多态与确诊年龄和激素受体状态显著相关。预后分析显示携带TT基因的患者预后不良，提示TT基因可能是乳腺癌预后不良的生物标志物。结论rs17506395基因多态性可作为乳腺癌的危险因素和预后指标，但其确切的作用机制有待进一步研究。
Backgroundp63, homologous to p53, has been investigated to be involved in various aspects of tumorigenesis and cancer progression. Recently, we have identified a functional single nucleotide polymorphism (SNP) rs17506395 (T>G) in p63 which was associated with female reproduction and ovarian cancer development. The present study aimed to evaluate the association of rs17506395 genotypes with breast cancer susceptibility, clinicopathological characteristics and prognosis.Patients and methodsTaqMan assay was used to genotype the rs17506395 polymorphism. The expression of p63 mRNA was determined by quantitative reverse-transcription PCR (qRT-PCR). Unconditional logistic regression and univariate Cox hazard regression analyses were performed to evaluate the association of rs17506395 with breast cancer susceptibility and prognosis respectively.ResultsFirst, we found that breast tumors with TT genotype exhibited higher level of p63 mRNA compared with other genotypes in breast cancer tissues, indicating that rs17506395 may be a functional single nucleotide polymorphism in breast cancer. Further investigation revealed that the presence of TT genotype was statistically correlated with increased risk for breast cancer, compared with genotypes containing the G allele (GG and GT). Moreover, a significant association between rs17506395 polymorphism and age at diagnosis and status of hormone receptor was observed. Consistently, prognostic analysis showed that patients carrying TT genotype represent unfavorable survival, suggesting that TT genotype may be a biomarker for poor prognosis in breast cancer.ConclusionOur data suggest that rs17506395 polymorphism can function as a risk factor and prognostic indicator for breast cancer, whereas precise mechanism underlying the function of this polymorphism needs further investigation.
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影响因子：
3.8
作者：
Yang, Qifeng;Moran, Meena S.;Haffty, Bruce G.
通讯作者：
Haffty, Bruce G.
细胞质 p63 表达增加乳腺上皮细胞的侵袭性和攻击性
影响因子：
9.2
作者：
Hsiao YH;Su YA;Tsai HD;Mason JT;Chou MC;Man YG
通讯作者：
Man YG
DOI：
--
发表时间：
2009
期刊：
--
影响因子：
--
作者：
S. Rodríguez;Tom R. Gaunt;I. Day
通讯作者：
S. Rodríguez;Tom R. Gaunt;I. Day
影响因子：
7.3
作者：
Pelosi, G;Pasini, F;Viale, G
通讯作者：
Viale, G
影响因子：
--
作者：
Bergholz, Johann;Xiao, Zhi-Xiong
通讯作者：
Xiao, Zhi-Xiong