High Throughput Sequencing for Clinical Tuberculosis: An Overview.

High Throughput Sequencing for Clinical Tuberculosis: An Overview.
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DOI:
10.3390/pathogens11111343
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发表时间:
2022-11-14
期刊:
Pathogens (Basel, Switzerland)
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高通量测序(HTS)可以鉴定临床样本中结核分枝杆菌DNA的存在,同时还提供药物敏感性信息。多项研究为探索HTS在结核病诊断中的临床应用提供了背景。工作流程的挑战,各种测序平台的优势和局限性,以及用于分析的工具,提供了一个框架,在该领域的进一步创新。
High throughput sequencing (HTS) can identify the presence of Mycobacterium tuberculosis DNA in a clinical sample while also providing information on drug susceptibility. Multiple studies have provided a context for exploring the clinical application of HTS for TB diagnosis. The workflow challenges, strengths and limitations of the various sequencing platforms, and tools used for analysis are presented to provide a framework for further innovations in the field.
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