In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels.
In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels.
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DOI：
10.3390/metabo11100657
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发表时间：
2021-09-28
期刊：
影响因子：
4.1
通讯作者：
Suvorov A
中科院分区：
文献类型：
--
作者：
Boutot ME;Whitcomb BW;Abdelouahab N;Baccarelli AA;Boivin A;Caku A;Gillet V;Martinez G;Pasquier JC;Zhu J;Takser L;St-Cyr L;Suvorov A
动物研究表明，在发育过程中接触多溴联苯醚会永久性地影响血液/肝脏的脂质平衡。没有人类研究评估子宫内接触持久性有机污染物（POP）和以后的生活脂质代谢之间的关联。在该试点项目中，对妊娠与环境组参与者分娩时的多溴二苯醚（BDE-47、BDE-99、BDE-100和BDE-153）和多氯联苯（PCB-138、PCB-153和PCB-180）的母体血浆水平进行了测定。对147名6-7岁儿童的血清进行了总胆固醇（TCh）、甘油三酯（TG）、低密度脂蛋白（LDL-C）和高密度脂蛋白（HDL-C）、总脂质（TL）和多溴二苯醚（PBDE）测定。一般线性回归用于估计母体持久性有机污染物和儿童血脂水平之间的关系，调整潜在的混杂因素，并调整儿童持久性有机污染物。在子宫内，BDE-99与儿童期甘油三酯水平较低有关（p = 0.003），与高密度脂蛋白胆固醇（p = 0.06）和总胆固醇（p = 0.07）无显著关系。母亲PCB-138与儿童期TG（p = 0.04）、LDL-C（p = 0.04）和TL（p = 0.02）水平较低相关。我们的数据表明，在子宫内暴露于持久性有机污染物可能与儿童循环脂质的长期持续下降有关，这表明肝脏中脂质积累增加，这是NAFLD发展的一种机制，与先前报道的动物数据一致。
Animal studies have shown that developmental exposures to polybrominated diphenyl ethers (PBDE) permanently affect blood/liver balance of lipids. No human study has evaluated associations between in utero exposures to persistent organic pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in participants of GESTation and Environment (GESTE) cohort. Total cholesterol (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), total lipids (TL), and PBDEs were determined in serum of 147 children at ages 6–7. General linear regression was used to estimate the relationship between maternal POPs and child lipid levels with adjustment for potential confounders, and adjustment for childhood POPs. In utero BDE-99 was associated with lower childhood levels of TG (p = 0.003), and non-significantly with HDL-C (p = 0.06) and TL (p = 0.07). Maternal PCB-138 was associated with lower childhood levels of TG (p = 0.04), LDL-C (p = 0.04), and TL (p = 0.02). Our data indicate that in utero exposures to POPs may be associated with long lasting decrease in circulating lipids in children, suggesting increased lipid accumulation in the liver, a mechanism involved in NAFLD development, consistent with previously reported animal data.
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影响因子：
24.5
作者：
Feldstein AE;Charatcharoenwitthaya P;Treeprasertsuk S;Benson JT;Enders FB;Angulo P
通讯作者：
Angulo P
影响因子：
6.9
作者：
Holterman, Ai-Xuan L.;Guzman, Grace;Holterman, Mark
通讯作者：
Holterman, Mark
DOI：
10.1016/j.jchromb.2005.09.020
发表时间：
2005-12-05
影响因子：
3
作者：
Covaci, A;Voorspoels, S
通讯作者：
Voorspoels, S
影响因子：
3.6
作者：
Helsley, Robert N.;Sui, Yipeng;Zhou, Changcheng
通讯作者：
Zhou, Changcheng
影响因子：
8.3
作者：
Goncharov, Alexey;Haase, Richard F.;Carpenter, David O.
通讯作者：
Carpenter, David O.