Tanshinone IIA: A Review of its Anticancer Effects.

Tanshinone IIA: A Review of its Anticancer Effects.
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DOI:
10.3389/fphar.2020.611087
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发表时间:
2020
影响因子:
5.6
通讯作者:
Fang L
Fang L
中科院分区:
医学2区
文献类型:
--
作者:
Fang ZY;Zhang M;Liu JN;Zhao X;Zhang YQ;Fang L

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丹参酮IIA (Tanshinone IIA)是从中药丹参的根和根茎中分离得到的一种具有药理意义的亲脂活性成分。Tan IIA目前在中国及周边国家用于治疗心血管系统、糖尿病、中风、关节炎、败血症等疾病。近年来,有报道称tan IIA对多种人类肿瘤细胞系具有广泛的抗肿瘤作用,但对tan IIA在肿瘤中的作用机制研究相对零散。本文综述了tan IIA抗癌作用的最新进展,并为tan IIA的临床应用提供了新的视角。
Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan IIA is currently used in China and other neighboring countries to treat patients with cardiovascular system, diabetes, apoplexy, arthritis, sepsis, and other diseases. Recently, it was reported that tan IIA could have a wide range of antitumor effects on several human tumor cell lines, but the research of the mechanism of tan IIA is relatively scattered in cancer. This review aimed to summarize the recent advances in the anticancer effects of tan IIA and to provide a novel perspective on clinical use of tan IIA.
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