Organoid models for mammary gland dynamics and breast cancer.
Organoid models for mammary gland dynamics and breast cancer.
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DOI：
10.1016/j.ceb.2020.05.003
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发表时间：
2020-10
影响因子：
7.5
通讯作者：
Gartner ZJ
中科院分区：
文献类型：
--
作者：
Srivastava V;Huycke TR;Phong KT;Gartner ZJ
乳腺是一种高度动态的组织，在怀孕和月经期间经历反复的生长和退化周期。它也是乳腺癌出现的部位。类器官提供了一种体外模型，保留了决定体内乳腺功能的几种细胞、结构和微环境特征，并极大地增进了我们对腺体生物学的理解。它们易于进行基因操作、实时成像和高通量筛选，促进了对腺体形态发生、结构维持、肿瘤进展和侵袭机制的研究。增强乳腺类器官模型的细胞和结构复杂性的机会仍然存在，包括纳入其他细胞类型和激素信号传导。
The mammary gland is a highly dynamic tissue that undergoes repeated cycles of growth and involution during pregnancy and menstruation. It is also the site from which breast cancers emerge. Organoids provide an in vitro model that preserves several of the cellular, structural and microenvironmental features that dictate mammary gland function in vivo, and have greatly advanced our understanding of glandular biology. Their tractability for genetic manipulation, live imaging and high throughput screening have facilitated investigation into the mechanisms of glandular morphogenesis, structural maintenance, tumor progression, and invasion. Opportunities remain to enhance cellular and structural complexity of mammary organoid models, including incorporating additional cell types and hormone signaling.
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影响因子：
64.5
作者：
Cheung KJ;Gabrielson E;Werb Z;Ewald AJ
通讯作者：
Ewald AJ
影响因子：
4.6
作者：
Huebner, Robert J.;Lechler, Terry;Ewald, Andrew J.
通讯作者：
Ewald, Andrew J.
影响因子：
14
作者：
Beck, Jennifer N.;Singh, Anirudha;Ewald, Andrew J.
通讯作者：
Ewald, Andrew J.
影响因子：
7.4
作者：
Davaadelger, Batzaya;Choi, Mi-Ran;Kim, J. Julie
通讯作者：
Kim, J. Julie
DOI：
10.1115/1.1449491
发表时间：
2002-04-01
影响因子：
1.7
作者：
Brodland, GW
通讯作者：
Brodland, GW