Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality.
Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality.
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DOI：
10.1038/s41408-020-00372-5
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发表时间：
2020-10-19
影响因子：
12.8
通讯作者：
San-Miguel J
中科院分区：
文献类型：
--
作者：
Martínez-López J;Mateos MV;Encinas C;Sureda A;Hernández-Rivas JÁ;Lopez de la Guía A;Conde D;Krsnik I;Prieto E;Riaza Grau R;Gironella M;Blanchard MJ;Caminos N;Fernández de Larrea C;Senin MA;Escalante F;de la Puerta JE;Giménez E;Martínez-Barranco P;Mateos JJ;Casado LF;Bladé J;Lahuerta JJ;de la Cruz J;San-Miguel J
There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate–severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19.
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影响因子：
7.5
作者：
Zhang, Xuhan;Song, Kaidi;Zheng, Changcheng
通讯作者：
Zheng, Changcheng
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影响因子：
50.5
作者：
Zhang, L.;Zhu, F.;Zhou, M.
通讯作者：
Zhou, M.
影响因子：
105.7
作者：
Collins, Gary S.;Reitsma, Johannes B.;Moons, Karel G. M.
通讯作者：
Moons, Karel G. M.
影响因子：
39
作者：
Wu, Chaomin;Chen, Xiaoyan;Song, Yuanlin
通讯作者：
Song, Yuanlin
DOI：
10.1093/jnci/djy088
发表时间：
2018-08-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Sauerbrei W;Taube SE;McShane LM;Cavenagh MM;Altman DG
通讯作者：
Altman DG