Portopulmonary hypertension in cirrhotic patients: Prevalence, clinical features and risk factors.
Portopulmonary hypertension in cirrhotic patients: Prevalence, clinical features and risk factors.
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肝硬化患者门脉性肺动脉高压：患病率、临床特征和危险因素
DOI：
10.3892/etm.2013.918
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发表时间：
2013-03
影响因子：
2.7
通讯作者：
Yang CQ
中科院分区：
文献类型：
--
作者：
Chen HS;Xing SR;Xu WG;Yang F;Qi XL;Wang LM;Yang CQ
门静脉高压症(POPH)的发生率和临床特征尚未得到充分的描述，目前尚不清楚POPH的严重程度与肝功能之间是否存在关联。此外，POPH的危险因素尚未确定。本研究的目的是确定POPH的患病率，描述其临床特征，并调查潜在的危险因素。我们对2011年3月至2012年5月在上海同济医院住院的100名肝硬变患者进行了研究。分析合并和不合并POPH患者的临床特点。测量可能与POPH相关的临床变量，并用心脏多普勒超声心动图测定肺动脉收缩压(PASP)。在这项研究中登记的100名患者中，有10名被诊断为POPH。其中7例为轻度，2例为中度，仅1例为重度；8例被归因于病毒感染。血吸虫性或酒精性肝硬变患者未检出POPH。POPH患者的Hb水平低于非POPH患者(P<0.0 1)，POPH的严重程度与−分级无明显相关性(R=0.0 6，P=0.0 9)。两组患者的Hb水平、丙型肝炎病毒(HCV)感染率和门静脉血栓形成发生率差异有统计学意义(P<；0.05)。Hb水平被认为是POPH的独立危险因素，门静脉血栓可能在POPH的发生发展过程中起重要作用。然而，POPH的严重程度与肝功能无关。
The incidence and clinical features of portopulmonary hypertension (POPH) have not been adequately described and it is currently unknown whether an association exists between the severity of POPH and liver function. Additionally, POPH risk factors are yet to be identified. The aim of this study was to determine the prevalence, describe the clinical features and investigate the potential risk factors of POPH. We conducted a study of 100 cirrhotic patients hospitalized between March 2011 and May 2012 at Tongji Hospital in Shanghai. The clinical characteristics of patients with and without POPH were analyzed. Clinical variables with a possible association with POPH were measured and pulmonary artery systolic pressure (PASP) was determined by cardiac Doppler echocardiography. Of the 100 patients enrolled in this study, 10 were diagnosed with POPH. Seven of the cases were mild, two were moderate and only one was severe; eight were attributed to viral infections. POPH was not detected in patients with schistosomal or alcoholic cirrhosis. Hemoglobin (Hb) levels were lower in patients with POPH compared to those without POPH (P<0.01) and the severity of POPH was not significantly correlated with Child-Pugh grade (R=−0.06, P=0.09). Hb levels, incidence of hepatitis C virus (HCV) infection and portal vein thrombosis differed between the two groups (P<0.05). Hb levels were identified as an independent risk factor associated with POPH and portal vein thrombosis may play an important role during the development of POPH. However, the severity of POPH was not associated with liver function.
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影响因子：
9.6
作者：
Chemla, D;Castelain, V;Hervé, P
通讯作者：
Hervé, P
影响因子：
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通讯作者：
Foster, Elyse
影响因子：
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作者：
Benjaminov, FS;Prentice, M;Wong, F
通讯作者：
Wong, F