The association between postpartum hemorrhage and postpartum depression: A Swedish national register-based study.
The association between postpartum hemorrhage and postpartum depression: A Swedish national register-based study.
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DOI：
10.1371/journal.pone.0255938
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Stephansson O
中科院分区：
文献类型：
--
作者：
Liu C;Butwick A;Sand A;Wikström AK;Snowden JM;Stephansson O
产后出血是孕产妇死亡和发病的重要原因。然而，目前尚不清楚经历产后出血的女性是否会增加患产后抑郁症的风险。检查产后出血是否与产后抑郁症有关。我们对486,476名瑞典出生的女性进行了一项基于国家登记的队列研究，她们在2007至2014年间生下了独生子女。我们排除了既往患有抑郁症或在分娩前服用抗抑郁药的女性。我们根据国际疾病分类第10版(ICD-10)抑郁症诊断代码或抗抑郁药的门诊处方将产后抑郁分类为产后12个月。我们使用COX比例风险模型，调整了母亲的社会人口学和产科因素。产后出血妇女产后抑郁发生率为2.0%(630/31,663)，非产后出血妇女产后抑郁发生率为1.9%(8601/455,059)。在我们的未调整分析中，产后出血与产后抑郁无关(未调整风险比(HR)=1.06，95%可信区间(CI)0.97-1.15)。在调整了母亲的年龄、产次、教育程度、同居状态、母亲吸烟状况和怀孕早期母亲的BMI、胎龄和出生体重后，这种关联没有明显的变化，可信区间与零重叠(调整后的HR=1.08，95%CI 0.99，1.17)。在瑞典一群无抑郁史的单身女性中，产后出血与产后抑郁无关。
Postpartum hemorrhage is an important cause of maternal death and morbidity. However, it is unclear whether women who experience postpartum hemorrhage are at an increased risk of postpartum depression. To examine whether postpartum hemorrhage is associated with postpartum depression. We conducted a national register-based cohort study of 486,476 Swedish-born women who had a singleton livebirth between 2007 and 2014. We excluded women with pre-existing depression or who filled a prescription for an antidepressant before childbirth. We classified postpartum depression up to 12 months after giving birth by the presence of an International Classification of Diseases, version 10 (ICD-10) diagnosis code for depression or a filled outpatient prescription for an antidepressant. We used Cox proportional hazard models, adjusting for maternal sociodemographic and obstetric factors. Postpartum depression was identified in 2.0% (630/31,663) of women with postpartum hemorrhage and 1.9% (8601/455,059) of women without postpartum hemorrhage. In our unadjusted analysis, postpartum hemorrhage was not associated with postpartum depression (unadjusted hazard ratio (HR) = 1.06, 95% confidence interval (CI) 0.97–1.15). After adjusting for maternal age, parity, education, cohabitation status, maternal smoking status, and early pregnancy maternal BMI, gestational age, and birthweight, the association did not appreciably change, with confidence intervals overlapping the null (adjusted HR = 1.08, 95% CI 0.99, 1.17). Within a population-based cohort of singleton women in Sweden with no prior history of depression, postpartum hemorrhage was not associated with postpartum depression.
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DOI：
10.1111/apa.15520
发表时间：
2021-03
期刊：
Acta paediatrica (Oslo, Norway : 1992)
影响因子：
--
作者：
Berg L;Ljunggren G;Hjern A
通讯作者：
Hjern A
影响因子：
4.3
作者：
Ladfors LV;Muraca GM;Butwick A;Edgren G;Stephansson O
通讯作者：
Stephansson O
影响因子：
5.8
作者：
Almond, Palo
通讯作者：
Almond, Palo
影响因子：
5.1
作者：
Kornfeld, Benjamin D.;Bair-Merritt, Megan H.;Solomon, Barry S.
通讯作者：
Solomon, Barry S.
影响因子：
2.9
作者：
Butwick, Alexander J.;Walsh, Eileen M.;Escobar, Gabriel J.
通讯作者：
Escobar, Gabriel J.