The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes1
The Resolution of Relapsing Fever Borreliosis Requires IgM and Is Concurrent with Expansion of B1b Lymphocytes1
复制标题
回归热疏螺旋体病的消退需要 IgM，并且与 B1b 淋巴细胞的扩增同时进行1
作者：
K. Alugupalli;R. Gerstein;Jianzhu Chen;E. Szomolanyi;R. Woodland;J. Leong
病原体清除率是发病率和死亡率的关键决定因素。我们试图描述由回归热细菌，赫氏疏螺旋体引起的菌血症个体发作的显著快速清除的免疫反应。SCID或Rag−/−小鼠不能分辨B。hermsii感染，表明T和/或B细胞的关键作用。缺乏T细胞的TCR−/−小鼠和缺乏T细胞和滤泡B细胞但不缺乏B1细胞和脾边缘区（MZ）B细胞的IL-7−/−小鼠有效地清除了B。赫姆斯。这些发现表明，B1细胞和/或MZ B细胞，两个B细胞亚群，已知参与快速，T-非依赖性反应，可能涉及。脾切除小鼠中度菌血症发作的有效解决表明，MZ B细胞在清除该细菌中不起主要作用。相反，缺乏B1细胞的xid小鼠比野生型小鼠遭受更严重的菌血症发作。假设B1细胞对B的清除至关重要。hermsii进一步得到B1 b的选择性扩增的支持（即，IgM高、IgD-/低、Mac 1 + CD 23-和CD 5-）细胞亚群，这与感染的最终消退一致。最后，选择性地不能分泌IgM（B1细胞产生的优势同种型）的小鼠完全不能清除B。赫姆斯。这些结果共同支持B1 b细胞产生控制和解决回归热疏螺旋体病所需的T-非依赖性IgM的模型。
The rate of pathogen clearance is a critical determinant of morbidity and mortality. We sought to characterize the immune response responsible for the remarkably rapid clearance of individual episodes of bacteremia caused by the relapsing fever bacterium, Borrelia hermsii. SCID or Rag−/− mice were incapable of resolving B. hermsii infection, indicating a critical role for T and/or B cells. TCR−/− mice, which lack T cells, and IL-7−/− mice, which are deficient in both T cells and follicular B cells, but not in B1 cells and splenic marginal zone (MZ) B cells, efficiently cleared B. hermsii. These findings suggested that B1 cells and/or MZ B cells, two B cell subsets that are known to participate in rapid, T-independent responses, might be involved. The efficient resolution of the episodes of moderate level bacteremia by splenectomized mice suggested that MZ B cells do not play the primary role in clearance of this bacterium. In contrast, xid mice, which are deficient in B1 cells, suffered more severe episodes of bacteremia than wild-type mice. The hypothesis that B1 cells are critical for clearance of B. hermsii was further supported by a selective expansion of the B1b (i.e., IgMhigh, IgD−/low, Mac1+ CD23−, and CD5−) cell subset in infected xid mice, which coincided with the eventual resolution of infection. Finally, mice selectively incapable of secreting IgM, the dominant isotype produced by B1 cells, were completely unable to clear B. hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis.
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影响因子：
4.3
作者：
Fischer, GM;Solt, LA;Rothstein, TL
通讯作者：
Rothstein, TL
影响因子：
32.4
作者：
Cariappa, A;Tang, M;Pillai, S
通讯作者：
Pillai, S
对伯氏疏螺旋体引起的严重关节炎的遗传易感性占主导地位，并且与组织中大量螺旋体的持续存在有关。
影响因子：
3.1
作者：
Yang,L;Weis,JH;Eichwald,E;Kolbert,CP;Persing,DH;Weis,JJ
通讯作者：
Weis,JJ
DOI：
10.1073/pnas.97.20.10930
发表时间：
2000-09
影响因子：
11.1
作者：
A. D. Wentworth;Lyn H. Jones;P. Wentworth;Kim D. Janda;Richard A. Lerner
通讯作者：
A. D. Wentworth;Lyn H. Jones;P. Wentworth;Kim D. Janda;Richard A. Lerner
影响因子：
4.4
作者：
Aaron B. Kantor;C. Merrill;L. Herzenberg;J. Hillson
通讯作者：
Aaron B. Kantor;C. Merrill;L. Herzenberg;J. Hillson