Clinical significance of umbilical region involvement in pemphigus vulgaris in a series of 81 ethnic Poles: a comparative analysis of the distribution of lesions in two infrequent locations.
Clinical significance of umbilical region involvement in pemphigus vulgaris in a series of 81 ethnic Poles: a comparative analysis of the distribution of lesions in two infrequent locations.
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DOI：
10.5114/ada.2021.102857
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发表时间：
2022-04
影响因子：
1.4
通讯作者：
Dmochowski, Marian
中科院分区：
文献类型：
--
作者：
Jalowska, Magdalena;Gornowicz-Porowska, Justyna;Seraszek-Jaros, Agnieszka;Bowszyc-Dmochowska, Monika;Kaczmarek, Elzbieta;Dmochowski, Marian
自身免疫性大疱性疾病是一种潜在的危及生命的皮肤病，表现为皮肤和/或粘膜水泡，根据临床表现、病灶周围组织的直接免疫荧光和循环自身抗体的血清检测进行诊断。有时，在肚脐病变可导致一个大疱性疾病的诊断。目的探讨波兰人寻常型天疱疮（PV）患者脐部及甲部病变的发生频率。回顾性分析2002-2020年诊断为PV组皮肤病的81例患者（男性31例，女性50例，平均年龄59岁）的照片档案。采用两比例的差异检验进行统计学分析，比较PV患者累及肚脐区与累及甲器的比例的差异。累及甲器的PV患者（12.3%）与累及脐区的PV患者（14.8%）之间差异无统计学意义（p = 0.4632）。在我们的PV患者系列中，只有女性在肚脐区域有病变。推测女性生殖系统与脐部周围PV病变的表达模式可能存在因果关系。意识到PV很少会影响脐区和指甲装置，应该有助于在某些情况下建立PV的诊断。脐周受累有助于在不易接近的区域病变的个体中进行DIF。
Autoimmune bullous diseases are potentially life-threatening dermatoses which present with cutaneous and/or mucosal blisters, diagnosed on the basis of clinical manifestations, direct immunofluorescence of perilesional tissue, and serum testing for circulating autoantibodies. Sometimes, lesions in the navel can lead to the diagnosis of a bullous disease. To assess the frequency of occurrence of pemphigus lesions located in the navel area and nail apparatus in pemphigus vulgaris (PV) in ethnic Poles. Eighty one patients (31 males and 50 females, mean age 59 years) with dermatoses of the PV group diagnosed in 2002-2020 were retrospectively analysed using their photographic files. Statistical analysis was performed using the difference test between two proportions to check the difference between the percentage of PV patients with navel area involvement and nail apparatus involvement. There was no statistically significant difference between PV patients with nail apparatus involvement (12.3%) and navel area involvement (14.8%) (p = 0.4632). Only females had lesions in the navel area in our series of PV patients. It is speculated that the causal relationship may exist between the female reproductive system and the pattern of expression of PV lesions around the umbilicus. The awareness that PV can infrequently affect the umbilical region and the nail apparatus should help in some cases to establish the diagnosis of PV. The periumbilical involvement can facilitate the performance of DIF in individuals with lesions in less accessible areas.
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影响因子：
3.9
作者：
Pietkiewicz, Pawel;Bowszyc-Dmochowska, Monika;Dmochowski, Marian
通讯作者：
Dmochowski, Marian
影响因子：
3.6
作者：
Daneshpazhooh, Maryam;Fatehnejad, Mina;Chams-Davatchi, Cheyda
通讯作者：
Chams-Davatchi, Cheyda
DOI：
10.2147/ccid.s128144
发表时间：
2017
期刊：
Clinical, cosmetic and investigational dermatology
影响因子：
--
作者：
Sävervall C;Sand FL;Thomsen SF
通讯作者：
Thomsen SF
影响因子：
32.4
作者：
Nakae, S;Komiyama, Y;Iwakura, Y
通讯作者：
Iwakura, Y
影响因子：
4.1
作者：
Oliveira Junior, J. V.;Maruta, C. W.;Aoki, V.
通讯作者：
Aoki, V.