Muscarinic cholinergic receptors in the human spinal cord: differential localization of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding sites
Muscarinic cholinergic receptors in the human spinal cord: differential localization of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding sites
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人脊髓中的毒蕈碱胆碱能受体：[3H]哌仑西平和[3H]奎宁环苯甲酸结合位点的差异定位
DOI：
10.1016/0006-8993(85)90854-6
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
R. Faull
中科院分区：
文献类型：
--
作者：
J. Villiger;R. Faull
用[~ 3 H]奎宁环二苯甲酸酯（QNB）和[~ 3 H]哌仑西平（PZ）体外标记人脊髓冰冻切片，然后进行放射自显影，研究了毒蕈碱胆碱能受体亚型在人脊髓中的定位。[3 H]QNB结合的最高密度位于第II层（胶状质）和第IX层（运动神经元）;相反，[3 H]PZ结合的最高密度位于第II层，其结合密度比第IX层高22-32%。这些结果表明，M1和M2毒蕈碱胆碱能受体亚型可能是差异定位于感觉和运动区的人脊髓。
The localization of muscarinic cholinergic receptor subtypes was studied in the human spinal cord using in vitro labelling of cryostat sections with [3H]quinuclidinylbenzilate (QNB) and [3H]pirenzepine (PZ) followed by autoradiography. The highest densities of [3H]QNB binding were localized in laminae II (substantia gelatinosa) and IX (motor neurons); in contrast, the highest density of [3H]PZ binding was localized to lamina II where the binding density was 22—32% higher than in lamina IX. These results suggest that the M1and M2muscarinic cholinergic receptor subtypes may be differentially localized in sensory and motor regions of the human spinal cord.
[3H]哌仑西平和[3H]奎宁环苯苯甲酸与大鼠脑中毒蕈碱胆碱能受体结合的比较。
DOI：
--
发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Luthin,GR;Wolfe,BB
通讯作者：
Wolfe,BB
[3h]pirenzepine 选择性识别大鼠大脑皮层中毒蕈碱胆碱能受体的高亲和力群体。
影响因子：
6.1
作者：
Watson,M;Roeske,WR;Yamamura,HI
通讯作者：
Yamamura,HI