Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES.

Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES.
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DOI:
10.1007/s40615-016-0246-8
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发表时间:
2017-06
影响因子:
3.9
通讯作者:
Sumner, Anne E.
Sumner, Anne E.
中科院分区:
医学4区
文献类型:
--
作者:
Duong, Michelle T.;Bingham, Brianna A.;Aldana, Paola C.;Chung, Stephanie T.;Sumner, Anne E.

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经过数十年的抵制,现在达成了真正的共识:除非压力的作用与基因和环境等传统公认的因素一起得到解决,否则疾病无法预防,甚至无法成功治疗。静态负荷测量通过静态负荷评分 (ALS) 进行量化,是评估应激生理反应最常用的方法之一。尽管人们普遍认为在 ALS 的计算中应包括三类生物标志物(心血管、代谢和免疫),但 ALS 的计算方式存在巨大差异。具体而言,对于应包括哪些生物标志物或应使用何种方法来确定生物标志物的值是否代表高风险尚未达成共识。在本视角中,我们概述了 21 项不同的 NHANES 研究中采用的方法。
After decades of resistance there is now a genuine consensus that disease cannot be prevented or even successfully treated unless the role of stress is addressed alongside traditionally recognized factors such as genes and the environment. Measurement of allostatic load, which is quantified by the allostatic load score (ALS), is one of the most frequently used methods to assess the physiologic response to stress. Even though there is universal agreement that in the calculation of ALS, biomarkers from three categories should be included (cardiovascular, metabolic and immune), enormous variation exists in how ALS is calculated. Specifically, there is no consensus on which biomarkers to include or the method which should be used to determine whether the value of a biomarker represents high risk. In this Perspective, we outline the approach taken in 21 different NHANES studies.
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