Novel subcellular localization for α-synuclein: possible functional consequences.
Novel subcellular localization for α-synuclein: possible functional consequences.
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DOI：
10.3389/fnana.2015.00017
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发表时间：
2015
影响因子：
2.9
通讯作者：
Przedborski S
中科院分区：
文献类型：
--
作者：
Guardia-Laguarta C;Area-Gomez E;Schon EA;Przedborski S
α-突触核蛋白（α-syn）是导致帕金森病（PD）发生突变或过表达的基因之一。最初，它被描述为突触末端蛋白，后来发现它定位于线粒体。线粒体相关膜（MAM）已经成为一个中央内质网（ER）亚细胞区室，细胞的关键功能发生在这里。这些结构域富含胆固醇和阴离子磷脂，是钙稳态、脂质转移和胆固醇代谢受到调节的地方。一些与线粒体动力学和功能有关的蛋白质也定位在这个区域。一些神经退行性疾病已经显示出MAM功能和常驻蛋白的改变，包括沙科-玛丽-图斯病和阿尔茨海默病（AD）。我们最近报道，在表达α-syn致病性突变的PD细胞和小鼠模型中，MAM功能下调。本文就α-syn在这些细胞结构域中的可能作用以及α-syn- mam干扰可能解释的PD的早期发病特征进行综述。
α-synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson’s Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic reticulum (ER) subcellular compartments where key functions of the cell occur. These domains, enriched in cholesterol and anionic phospholipids, are where calcium homeostasis, lipid transfer, and cholesterol metabolism are regulated. Some proteins, related to mitochondrial dynamics and function, are also localized to this area. Several neurodegenerative diseases have shown alterations in MAM functions and resident proteins, including Charcot Marie-Tooth and Alzheimer’s disease (AD). We have recently reported that MAM function is downregulated in cell and mouse models of PD expressing pathogenic mutations of α-syn. This review focuses on the possible role of α-syn in these cellular domains and the early pathogenic features of PD that could be explained by α-syn-MAM disturbances.
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影响因子：
4.3
作者：
Csordas, Gyoergy;Hajnoczky, Gyoergy
通讯作者：
Hajnoczky, Gyoergy
影响因子：
3.5
作者：
Chen H;Chan DC
通讯作者：
Chan DC
影响因子：
11.4
作者：
Area-Gomez, Estela;Castillo, Maria Del Carmen Lara;Tambini, Marc D.;Guardia-Laguarta, Cristina;de Groof, Ad J. C.;Madra, Moneek;Ikenouchi, Junichi;Umeda, Masato;Bird, Thomas D.;Sturley, Stephen L.;Schon, Eric A.
通讯作者：
Schon, Eric A.
影响因子：
17.1
作者：
Cooper O;Seo H;Andrabi S;Guardia-Laguarta C;Graziotto J;Sundberg M;McLean JR;Carrillo-Reid L;Xie Z;Osborn T;Hargus G;Deleidi M;Lawson T;Bogetofte H;Perez-Torres E;Clark L;Moskowitz C;Mazzulli J;Chen L;Volpicelli-Daley L;Romero N;Jiang H;Uitti RJ;Huang Z;Opala G;Scarffe LA;Dawson VL;Klein C;Feng J;Ross OA;Trojanowski JQ;Lee VM;Marder K;Surmeier DJ;Wszolek ZK;Przedborski S;Krainc D;Dawson TM;Isacson O
通讯作者：
Isacson O
DOI：
10.1097/01.jnen.0000179050.54522.5a
发表时间：
2005-09-01
影响因子：
3.2
作者：
Dalfó, E;Portero-Otín, M;Ferrer, I
通讯作者：
Ferrer, I