Global hormone profiling of murine placenta reveals Secretin expression.
Global hormone profiling of murine placenta reveals Secretin expression.
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DOI：
10.1016/j.placenta.2011.08.013
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发表时间：
2011-11
期刊：
影响因子：
3.8
通讯作者：
Baker, J. C.
中科院分区：
文献类型：
--
作者：
Knox, K.;Leuenberger, D.;Penn, A. A.;Baker, J. C.
To elucidate and categorize the murine placental hormones expressed across gestation, including the expression of hormones with previously undescribed roles. Expression levels of all genes with known or predicted hormone activity expressed in two separate tissues, the placenta and maternal decidua, were assessed across a timecourse spanning the full lifetime of the placenta. Novel expression patterns were confirmed by in situ hybridization and protein level measurements. A combination of temporal and spatial information defines five groups that can accurately predict the patterns of uncharacterized hormones. Our analysis identified Secretin, a novel placental hormone that is expressed specifically by the trophoblast at levels many times greater than in any other tissue. The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
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DOI：
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发表时间：
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影响因子：
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通讯作者：
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DOI：
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DOI：
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发表时间：
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影响因子：
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