Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American men.
Association of neighborhood gentrification with prostate cancer and immune markers in African American and European American men.
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先前的研究表明，邻里剥夺增加了致命的前列腺癌的风险。然而，社区中产阶级化在前列腺癌发展和结果中的作用仍然知之甚少。我们在一个不同的队列中研究了中产阶级化与前列腺癌和血清蛋白质组定义的炎症和免疫功能的关系。病例对照研究包括769例病例[405例非洲裔美国人（AA），364例欧洲裔美国人（EA）男性]和1023例对照（479例AA和544例EA），其中219例全因死亡和59例前列腺癌特异性死亡。地理编码与来自美国人口普查数据的社区中产阶级化指数（NGI）相关联。考克斯和逻辑回归，MANOVA，被用来确定NGI，连续或五分位数（Q），和结果之间的关联。调整个体社会经济地位（SES）后，在所有男性中，持续NGI与前列腺癌呈正相关（比值比[OR] 1.07，95%置信区间[CI] 1.01-1.14）。AA和低收入男性在居住在中等中产阶级化的区域时患前列腺癌的几率最高，而EA男性在SES调整的分析中随着中产阶级化的增加，患区域性/转移性癌症的几率降低。在SES校正的考克斯回归分析中，持续NGI也与局部疾病男性和低收入男性的死亡率相关。NGI与血清蛋白质组定义的趋化性、炎症和肿瘤免疫抑制无关。研究结果表明，社区中产阶级化与前列腺癌和死亡率在这个不同的人群，虽然协会是异质性的亚组。这些观察结果表明，不断变化的社区社会经济环境可能会影响前列腺癌的风险和结果，可能是通过多因素机制。
Prior studies showed that neighborhood deprivation increases the risk of lethal prostate cancer. However, the role of neighborhood gentrification in prostate cancer development and outcome remains poorly understood. We examined the relationships of gentrification with prostate cancer and serum proteome‐defined inflammation and immune function in a diverse cohort. The case–control study included 769 cases [405 African American (AA), 364 European American (EA) men] and 1023 controls (479 AA and 544 EA), with 219 all‐cause and 59 prostate cancer‐specific deaths among cases. Geocodes were linked to a neighborhood gentrification index (NGI) derived from US Census data. Cox and logistic regression, and MANOVA, were used to determine associations between NGI, as continuous or quintiles (Q), and outcomes. Adjusting for individual socioeconomic status (SES), continuous NGI was positively associated with prostate cancer among all men (odds ratio [OR] 1.07, 95% confidence interval [CI] 1.01–1.14). AA and low‐income men experienced the highest odds of prostate cancer when residing in tracts with moderate gentrification, whereas EA men experienced reduced odds of regional/metastatic cancer with increased gentrification in SES‐adjusted analyses. Continuous NGI also associated with mortality among men presenting with localized disease and low‐income men in SES‐adjusted Cox regression analyses. NGI was not associated with serum proteome‐defined chemotaxis, inflammation, and tumor immunity suppression. Findings show that neighborhood gentrification associates with prostate cancer and mortality in this diverse population albeit associations were heterogenous within subgroups. The observations suggest that changing neighborhood socioeconomic environments may affect prostate cancer risk and outcome, likely through multifactorial mechanisms.
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通讯作者：
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