Stress effects on declarative memory retrieval are blocked by a β-adrenoceptor antagonist in humans
Stress effects on declarative memory retrieval are blocked by a β-adrenoceptor antagonist in humans
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人类中的β-肾上腺素受体拮抗剂可以阻断压力对陈述性记忆检索的影响
DOI：
10.1016/j.psyneuen.2008.10.009
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发表时间：
2009
影响因子：
3.7
通讯作者：
H. Schächinger
中科院分区：
文献类型：
--
作者：
L. Schwabe;Sonja Römer;Steffen Richter;Svenja Dockendorf;Boris Bilak;H. Schächinger
先前的证据表明，应激激素对记忆巩固的影响依赖于同时发生的情绪唤醒诱导的去甲肾上腺素能活动。在这里，我们询问这是否也适用于应激对记忆提取的影响，并假设给予β-肾上腺素受体拮抗剂普萘洛尔会阻断应激对陈述性和程序性提取表现的影响。在一项双盲、安慰剂对照、交叉研究中，44名健康的年轻男性学习了一系列情感和中性词（陈述性记忆任务），并完成了一项序列反应时间任务（程序性记忆任务）。第二天，参与者口服安慰剂或40 mg普萘洛尔。一小时后，他们在保留测试前30分钟暴露于压力（社会评估冷加压测试（SECPT））或对照条件。压力选择性地增强了情绪唤起词的提取。普萘洛尔预处理对记忆本身没有影响，但阻断了应激诱导的情感词记忆增强，证实了去甲肾上腺素能活性在应激对记忆提取的影响中的重要性。中性词语和程序性任务的记忆既不受压力的影响，也不受普萘洛尔的影响。目前的研究结果表明，压力（激素）对情绪记忆提取的影响需要同时去甲肾上腺素能激活。程序性记忆提取和中性言语材料的提取似乎不太容易受到压力的影响。
Previous evidence indicates that stress hormone effects on memory consolidation depend on concurrent emotional arousal-induced noradrenergic activity. Here, we asked whether this is also true for stress effects on memory retrieval and hypothesized that administration of the β-adrenoceptor antagonist propranolol would block the effects of stress on declarative and procedural retrieval performance. In a double-blind, placebo-controlled, crossover study, 44 healthy young men learned a list of emotional and neutral words (declarative memory task) and completed a serial reaction time task (procedural memory task). On the following day, participants received either a placebo or 40mg propranolol orally. One hour later, they were exposed to stress (socially evaluated cold pressor test (SECPT)) or a control condition 30min prior to retention testing. Stress selectively enhanced the retrieval of emotionally arousing words. Pretreatment with propranolol had no effect on memory alone but blocked the stress-induced memory enhancement for emotional words, confirming the importance of noradrenergic activity in stress effects on memory retrieval. Memory for neutral words and the procedural task was neither affected by stress nor by propranolol. The present findings suggest that stress (hormone) effects on emotional memory retrieval require concurrent noradrenergic activation. Procedural memory retrieval and the retrieval of neutral verbal material appear to be less susceptible to stress.
DOI：
10.1073/pnas.0601874103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Roozendaal, B;Okuda, S;McGaugh, JL
通讯作者：
McGaugh, JL
影响因子：
2
作者：
Cahill, L;Gorski, L;Le, K
通讯作者：
Le, K