NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes.
NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes.
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DOI：
10.3389/fphar.2017.00798
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发表时间：
2017
影响因子：
5.6
通讯作者：
Kulkarni YA
中科院分区：
文献类型：
--
作者：
Suryavanshi SV;Kulkarni YA
糖尿病是一种影响全世界大部分人口的代谢紊乱。NF-κβ在糖尿病血管并发症的发病机制中起重要作用。持续性高血糖激活NF-κβ，触发各种细胞因子、趋化因子和细胞粘附分子的表达。NF-κβ过度表达TNF-α、白细胞介素、TGF-β、Bcl 2等促炎蛋白和促凋亡基因是血管功能障碍的关键危险因素。NF-κβ过表达还触发内皮细胞钙化，导致内皮功能障碍和进一步的血管并发症。抑制NF-κβ促炎通路是治疗糖尿病血管并发症的新靶点。各种天然和合成的NF-κβ抑制剂已被研究用于糖尿病并发症的管理。最近的临床前和临床研究证实NF-κβ是治疗糖尿病血管并发症的有希望的靶点。
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-κβ that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-α, interleukins, TGF-β, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-κβ is key risk factor in vascular dysfunction. NF-κβ over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-κβ pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-κβ have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-κβ as promising target in the management of vascular complications of diabetes.
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