Possible role of central interleukins on the anorexigenic effect of lipopolysaccharide in chicks
Possible role of central interleukins on the anorexigenic effect of lipopolysaccharide in chicks
复制标题
中枢白细胞介素对脂多糖引起雏鸡厌食作用的可能作用
作者：
T. Tachibana;T. Kodama;S. Yamane;Ryosuke Makino;Sakirul Khan;M. Cline
摘要1.本研究旨在探讨中枢白细胞介素1β（IL 1 β）、白细胞介素6（IL 6）和白细胞介素8（IL 8）对雏鸡摄食行为的影响，以及中枢白细胞介素与脂多糖（LPS）诱导的厌食症的关系。2.腹腔内注射LPS可显著抑制大鼠的摄食行为，并显著增加间脑IL 1 β和IL 8的mRNA表达，而IL 6则有增加的趋势。3.侧脑室注射200 ng IL 1 β后60 min摄食量显著减少，而IL 6和IL 8则无明显影响。4. IA注射这些IL（200 ng）对雏鸡的食物摄取没有影响。5.侧脑室注射200 ng IL 1 β对饮水量和血浆皮质酮浓度无影响，提示中枢IL 1 β可能与饮水行为和下丘脑-垂体-肾上腺轴的调节无关。6.本研究表明，中枢IL 1 β可能与雏鸡摄食抑制有关，而IL 6和IL 8则与之无关。
ABSTRACT 1. The purpose of the present study was to determine if central interleukin-1β (IL1β), interleukin-6 (IL6) and interleukin-8 (IL8) affect feeding behaviour in chicks (Gallus gallus) and examine if central interleukins are related to the lipopolysaccharide (LPS)-induced anorexia. 2. Intra-abdominal (IA) injection of LPS significantly suppressed feeding behaviour and significantly increased mRNA expression of IL1β and IL8 in the diencephalon when compared to the control group, while IL6 tended to be increased. 3. Intracerebroventricular (ICV) injection of 200 ng IL1β significantly decreased food intake at 60 min after the injection while IL6 and IL8 had no effect. 4. IA injection of these ILs (200 ng) had no effect on food intake in chicks. 5. ICV injection of 200 ng IL1β did not affect water intake and plasma corticosterone concentration, suggesting that central IL1β might not be related to the regulation of drinking behaviour and the hypothalamus–pituitary–adrenal axis. 6. The present study demonstrated that central IL1β but not IL6 and IL8 might be related to the inhibition of feeding in chicks.
影响因子：
4.4
作者：
L. Ehrlich;Shuxian Hu;W. Sheng;Richard Sutton;G. Rockswold;Phillip K. Peterson;Chun C. Chao
通讯作者：
L. Ehrlich;Shuxian Hu;W. Sheng;Richard Sutton;G. Rockswold;Phillip K. Peterson;Chun C. Chao
影响因子：
56.9
作者：
HALAAS, JL;GAJIWALA, KS;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM