High risk of adverse birth outcomes among adolescents living with HIV in Botswana compared to adult women living with HIV and adolescents without HIV.
High risk of adverse birth outcomes among adolescents living with HIV in Botswana compared to adult women living with HIV and adolescents without HIV.
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DOI：
10.1186/s12884-022-04687-y
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发表时间：
2022-04-30
影响因子：
3.1
通讯作者：
Shapiro, Roger L.
中科院分区：
文献类型：
--
作者：
Jackson-Gibson, Maya;Zash, Rebecca;Mussa, Aamirah;Caniglia, Ellen C.;Diseko, Modiegi;Mayondi, Gloria;Mabuta, Judith;Morroni, Chelsea;Mmalane, Mompati;Lockman, Shahin;Makhema, Joseph;Shapiro, Roger L.
青春期女孩感染艾滋病毒的可能性是同龄男孩的三倍。以前的研究发现，青少年怀孕与产妇发病率和婴儿死亡率增加之间存在关联，但很少有研究评估艾滋病毒感染对青少年母婴结局的影响。特塞帕莫的研究从博茨瓦纳政府产科病房的产科记录中提取了孕产妇和婴儿的数据。我们根据艾滋病毒状况，在18个特塞帕莫地点评估了2014年8月至2020年8月期间所有单胎妊娠的孕产妇并发症和不良分娩结果，这些地点包括青少年(定义为10-19 岁)和成年人(定义为20-35 岁)。采用完全病例分析方法进行单因素和多因素Logistic回归分析，以评估预后的差异。这项分析包括142,258名独生子女，其中21,133名(14.9%)为青少年，121,125名(85.1%)为成人。成人艾滋病毒携带者比例(N = 22,114，22.5%)高于青少年(N = 1593，7.6%)。在青少年中，最不利的生育结局的比例更高。在青少年中，艾滋病毒携带者增加了贫血(AOR = 1.89，95%CI 1.66，2.15)和剖宫产(AOR = 1.49，95%CI 1.3，1.72)的风险，以及早产(AOR = 1.15，95%CI 1.0，1.32)，极早产(AOR = 1.35，95%CI 1.0，1.8)，小于胎龄(AOR = 1.37，95%CI 1.20，1.58)，胎龄极小(AOR = 为1.46，95%CI为1.20，1.79)。在博茨瓦纳，青少年怀孕和青少年艾滋病毒感染率仍然很高。与成人相比，青少年产生不良母婴结局的风险更高，在感染艾滋病毒的青少年中结局最差。将这一年龄段的艾滋病毒预防和计划生育战略联系起来可能有助于最大限度地减少这一本已脆弱的人群中出生结局不佳的婴儿的数量。
Adolescent girls are three times more likely to be living with HIV than boys of the same age. Prior studies have found associations between adolescent pregnancies and increased maternal morbidity and infant mortality, but few studies have assessed the impact of HIV infection on maternal and infant outcomes in adolescents. The Tsepamo Study abstracts maternal and infant data from obstetric records in government maternity wards in Botswana. We assessed maternal complications and adverse birth outcomes for all singleton pregnancies from August 2014 to August 2020 at eighteen Tsepamo sites among adolescents (defined as 10–19 years of age) and adults (defined as 20–35 years of age), by HIV status. Univariate and multivariate logistic regression using a complete case analysis method were used to evaluate differences in outcomes. This analysis included 142,258 singleton births, 21,133 (14.9%) to adolescents and 121,125 (85.1%) to adults. The proportion of adults living with HIV (N = 22,114, 22.5%) was higher than adolescents (N = 1593, 7.6%). The proportion of most adverse birth outcomes was higher in adolescents. Among adolescents, those with HIV had increased likelihoods of anemia (aOR = 1.89, 95%CI 1.66, 2.15) and cesarean sections (aOR = 1.49, 95%CI 1.3,1.72), and infants with preterm birth (aOR = 1.15, 95%CI 1.0, 1.32), very preterm birth (aOR = 1.35, 95%CI 1.0,1.8), small for gestational age (aOR = 1.37, 95%CI 1.20,1.58), and very small for gestational age (aOR = 1.46, 95%CI 1.20, 1.79). Adolescent pregnancy and adolescent HIV infection remain high in Botswana. Adolescents have higher risk of adverse maternal and infant birth outcomes than adults, with the worst outcomes among adolescents living with HIV. Linking HIV prevention and family planning strategies for this age group may help minimize the number of infants with poor birth outcomes among this already vulnerable population.
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影响因子：
4.5
作者：
MacCarthy S;Saya U;Samba C;Birungi J;Okoboi S;Linnemayr S
通讯作者：
Linnemayr S
DOI：
10.1016/0028-2243(94)02012-4
发表时间：
1995-03-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
MAHFOUZ, AAR;ELSAID, MM;HAMID, AM
通讯作者：
HAMID, AM
影响因子：
2.4
作者：
Orvos, H;Nyirati, I;Kovács, L
通讯作者：
Kovács, L
影响因子：
1.8
作者：
Kirbas, Ayse;Gulerman, Hacer C.;Daglar, Korkut
通讯作者：
Daglar, Korkut
影响因子：
9.8
作者：
Conroy AL;McDonald CR;Gamble JL;Olwoch P;Natureeba P;Cohan D;Kamya MR;Havlir DV;Dorsey G;Kain KC
通讯作者：
Kain KC