Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: the China Health and Retirement Longitudinal Study.
Early-life exposure to severe famine and subsequent risk of depressive symptoms in late adulthood: the China Health and Retirement Longitudinal Study.
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DOI：
10.1192/bjp.2018.116
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Li C;Miles T;Shen L;Shen Y;Liu T;Zhang M;Li S;Huang C
1959年至1961年的中国大饥荒造成了大范围的饥荒。它与抑郁症状的长期关联尚未研究。估计抑郁症状的负担以及饥饿暴露与抑郁症状的关联。中国健康与退休纵向研究是一项针对17,708名年龄≥45岁的中国成年人的全国性代表性调查。倾向评分匹配和改良泊松回归被用来评估自我报告的饥饿暴露在早期生活和抑郁症状之间的关联整体参与者。这种协会也进行了评估，通过发展阶段，使用修改后的泊松回归和逻辑回归。2011年抑郁症状患病率为26.19%（95%置信区间[CI]：25.11%-27.27%）。根据因饥饿而失去家庭成员的定义，该人群中有11.60%（95%CI：10.08%-13.12%）经历了严重饥荒。与没有饥饿的参与者相比，那些在胎儿期，儿童中期，青少年和成年早期经历严重饥饿的参与者有1.87（95%CI：1.36-2.55）、1.54（95%CI：1.23-1.94）、1.47（95%CI：1.09-2.00）和1.77（95%CI：1.42-2.21）倍。妊娠前两个月是胎儿期的关键时间窗，严重饥饿与抑郁症状的关联性较强。婴儿、幼儿、学龄前或青少年阶段的饥荒与抑郁症状无关。总体而言，饥荒占该人群抑郁症状负担的13.6%。CGF对中国抑郁症状负担的贡献很大。
The Chinese Great Famine (CGF) caused widespread starvation in 1959–61. Its long-term association with depressive symptoms has not been studied. To estimate the burden of depressive symptoms and the association of famine exposure with depressive symptoms. The China Health and Retirement Longitudinal Study is a nationwide representative survey among 17,708 Chinese adults aged ≥45. Propensity score matching and modified Poisson regression were used to evaluate association between self-reported famine exposure in early life and depressive symptoms among the overall participants. Such associations were also assessed by developmental stages using the modified Poisson regression and logistic regression. The prevalence of depressive symptoms was 26.19% (95% confidence interval [CI]: 25.11%-27.27%) in 2011. As defined by loss of family members due to starvation, 11.60% (95% CI: 10.08%-13.12%) of this population experienced severe famine. When compared to participants without starvation, those experienced severe famine during fetal, mid-childhood, young-teen, and early adulthood stages had 1.87 (95% CI: 1.36–2.55), 1.54 (95% CI: 1.23–1.94), 1.47 (95% CI: 1.09–2.00), and 1.77 (95% CI: 1.42–2.21) times higher odds to have depressive symptoms in late adulthood, respectively. The first two trimesters of pregnancy were critical time window during the fetal stage that severe famine had stronger association with depressive symptoms. Famine during the infant, toddler, preschool, or teenager stages was not associated with depressive symptoms. Overall, famine contributed to 13.6% of the depressive symptoms burden in this population. The CGF contributed substantially to the burden of depressive symptoms in China.
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作者：
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DOI：
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