Mitochondrial Toxicity.
Mitochondrial Toxicity.
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DOI：
10.1093/toxsci/kfy008
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发表时间：
2018-03-01
期刊：
影响因子：
--
通讯作者：
Mello DF
中科院分区：
文献类型：
--
作者：
Meyer JN;Hartman JH;Mello DF
近几十年来，药物和污染物对线粒体的毒性作用迅速增加。研究人员还记录了许多导致线粒体疾病的遗传差异，目前据报道，4,300人中有101人受到影响，这在线粒体毒性中产生了大量潜在的基因-环境相互作用。我们简要回顾了这段历史，然后重点介绍了线粒体研究的前沿领域，包括线粒体活性氧在信号传导中的作用;增加了对线粒体稳态所涉及的基本生物学过程的理解;（DNA维持和诱变、线粒体应激反应途径、融合和分裂、自噬和生物发生以及胞吐作用）;这些问题包括：特定细胞类型中线粒体压力导致的全身性影响;线粒体参与免疫功能;越来越多的证据表明线粒体毒性具有长期影响;线粒体-表观遗传相互作用;以及采用更新的方法测试化学品的线粒体毒性。我们还讨论了潜在的重要性，线粒体应激激素的影响。最后，我们评论未来的研究领域，我们认为至关重要的线粒体毒理学，包括临床，实验室和流行病学（人类和野生动物）研究的整合增加;提高对人类生物标志物的理解;并纳入影响线粒体的其他因素，如饮食，运动，年龄和非化学应激源。
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creating a large number of potential gene-environment interactions in mitochondrial toxicity. We briefly review this history, and then highlight cutting-edge areas of mitochondrial research including the role of mitochondrial reactive oxygen species in signaling; increased understanding of fundamental biological processes involved in mitochondrial homeostasis (DNA maintenance and mutagenesis, mitochondrial stress response pathways, fusion and fission, autophagy and biogenesis, and exocytosis); systemic effects resulting from mitochondrial stresses in specific cell types; mitochondrial involvement in immune function; the growing evidence of long-term effects of mitochondrial toxicity; mitochondrial-epigenetic cross-talk; and newer approaches to test chemicals for mitochondrial toxicity. We also discuss the potential importance of hormetic effects of mitochondrial stressors. Finally, we comment on future areas of research we consider critical for mitochondrial toxicology, including increased integration of clinical, experimental laboratory, and epidemiological (human and wildlife) studies; improved understanding of biomarkers in the human population; and incorporation of other factors that affect mitochondria, such as diet, exercise, age, and nonchemical stressors.
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影响因子：
14.9
作者：
Bess AS;Crocker TL;Ryde IT;Meyer JN
通讯作者：
Meyer JN
影响因子：
4.3
作者：
Chan, Katie;Truong, Don;O'Brien, Peter J
通讯作者：
O'Brien, Peter J
影响因子：
4.5
作者：
Blajszczak C;Bonini MG
通讯作者：
Bonini MG
DOI：
10.1073/pnas.1404651111
发表时间：
2014-07-01
影响因子：
11.1
作者：
Davis, Chung-ha O.;Kim, Keun-Young;Marsh-Armstrong, Nicholas
通讯作者：
Marsh-Armstrong, Nicholas
影响因子：
2.1
作者：
Bookman, Ebony B.;McAllister, Kimberly;Gillanders, Elizabeth;Wanke, Kay;Balshaw, David;Rutter, Joni;Reedy, Jill;Shaughnessy, Daniel;Agurs-Collins, Tanya;Paltoo, Dina;Atienza, Audie;Bierut, Laura;Kraft, Peter;Fallin, M. Daniele;Perera, Frederica;Turkheimer, Eric;Boardman, Jason;Marazita, Mary L.;Rappaport, Stephen M.;Boerwinkle, Eric;Suomi, Stephen J.;Caporaso, Neil E.;Hertz-Picciotto, Irva;Jacobson, Kristen C.;Lowe, William L.;Goldman, Lynn R.;Duggal, Priya;Gunnar, Megan R.;Manolio, Teri A.;Green, Eric D.;Olster, Deborah H.;Birnbaum, Linda S.
通讯作者：
Birnbaum, Linda S.