Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop.
Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop.
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DOI：
10.1002/gepi.20571
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发表时间：
2011-05
影响因子：
2.1
通讯作者：
Birnbaum, Linda S.
中科院分区：
文献类型：
--
作者：
Bookman, Ebony B.;McAllister, Kimberly;Gillanders, Elizabeth;Wanke, Kay;Balshaw, David;Rutter, Joni;Reedy, Jill;Shaughnessy, Daniel;Agurs-Collins, Tanya;Paltoo, Dina;Atienza, Audie;Bierut, Laura;Kraft, Peter;Fallin, M. Daniele;Perera, Frederica;Turkheimer, Eric;Boardman, Jason;Marazita, Mary L.;Rappaport, Stephen M.;Boerwinkle, Eric;Suomi, Stephen J.;Caporaso, Neil E.;Hertz-Picciotto, Irva;Jacobson, Kristen C.;Lowe, William L.;Goldman, Lynn R.;Duggal, Priya;Gunnar, Megan R.;Manolio, Teri A.;Green, Eric D.;Olster, Deborah H.;Birnbaum, Linda S.
虽然人们认识到，许多常见的复杂疾病是多种遗传和环境风险因素的结果，但基因-环境相互作用的研究仍然是一个挑战，迄今为止取得的成功有限。鉴于目前的科学状况，NIH通过邀请来自不同学科的专家就基因-环境相互作用研究的未来方向提出建议，寻求加快健康和疾病中基因-环境相互作用研究的方法。美国国立卫生研究院基因-环境相互作用研讨会的与会者一致认为，有必要继续强调对疾病中遗传和环境因素之间相互作用的研究，研究需要围绕多方面的方法进行设计，以反映疾病，暴露属性和人类发展的相关阶段的差异。与会者指出，有针对性的和不可知的方法都有优点和缺点，以评估遗传和环境因素及其相互作用的主要影响。在研讨会上代表的独特观点允许探索不同的研究设计和分析策略，并传达了跨学科方法的必要性，包括数据共享和数据协调，以充分探索基因-环境相互作用。此外，与会者还强调，在正在进行的研究和新的研究中，仍然需要高质量的环境暴露措施和新的基因组技术。
Although it is recognized that many common complex diseases are a result of multiple genetic and environmental risk factors, studies of gene-environment interaction remain a challenge and have had limited success to date. Given the current state-of-the-science, NIH sought input on ways to accelerate investigations of gene-environment interplay in health and disease by inviting experts from a variety of disciplines to give advice about the future direction of gene-environment interaction studies. Participants of the NIH Gene-Environment Interplay Workshop agreed that there is a need for continued emphasis on studies of the interplay between genetic and environmental factors in disease and that studies need to be designed around a multifaceted approach to reflect differences in diseases, exposure attributes, and pertinent stages of human development. The participants indicated that both targeted and agnostic approaches have strengths and weaknesses for evaluating main effects of genetic and environmental factors and their interactions. The unique perspectives represented at the workshop allowed the exploration of diverse study designs and analytical strategies, and conveyed the need for an interdisciplinary approach including data sharing, and data harmonization to fully explore gene-environment interactions. Further, participants also emphasized the continued need for high-quality measures of environmental exposures and new genomic technologies in ongoing and new studies.
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影响因子：
11
作者：
通讯作者：
--
DOI：
10.1038/nrg2579
发表时间：
2009-06
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Cordell HJ
通讯作者：
Cordell HJ
影响因子：
3.7
作者：
Patel CJ;Bhattacharya J;Butte AJ
通讯作者：
Butte AJ
在研究中，在Indig2和PFKP中的常见变体与肥胖症中基于全基因组的相关性的不复制在18,014个DANES的研究中。
影响因子：
3.7
作者：
Andreasen CH;Mogensen MS;Borch-Johnsen K;Sandbaek A;Lauritzen T;Sørensen TI;Hansen L;Almind K;Jørgensen T;Pedersen O;Hansen T
通讯作者：
Hansen T
影响因子：
2.1
作者：
Mukherjee, Bhramar;Ahn, Jaeil;Chatterjee, Nilanjan
通讯作者：
Chatterjee, Nilanjan