Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps
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未成熟的成年神经元重塑 CA3 空间图的独特潜力
DOI：
10.1101/2022.09.14.507576
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
E. Kropff
中科院分区：
文献类型：
--
作者：
Matías Mugnaini;M. Trinchero;A. F. Schinder;Verónica C. Piatti;E. Kropff
哺乳动物的海马回路通过成年神经发生经历广泛的重塑。虽然这一过程已被广泛研究，但成年颗粒细胞（aGC）对海马空间操作的具体贡献仍然未知。在这里，我们表明，自由觅食小鼠中 4 周龄（年轻）aGC 的光遗传学激活会产生近端 CA3 空间图的不可逆重新配置，同时很少引起神经活动。在随后的几天中刺激同一神经元组可以增强 CA3 神经元的功效，但无法诱导进一步的重新映射。相反，刺激 8 周龄（成熟）aGC 可以可靠地激活 CA3 细胞，但不会产生空间图的改变。我们的结果揭示了年轻 aGC 在重塑 CA3 表征中的独特作用，这种潜力可能会随着成熟而耗尽并消失。这种能力有助于生成支持模式分离的正交下游代码。
Mammalian hippocampal circuits undergo extensive remodeling through adult neurogenesis. While this process has been widely studied, the specific contribution of adult-born granule cells (aGCs) to spatial operations in the hippocampus remains unknown. Here we show that optogenetic activation of 4-week-old (young) aGCs in free-foraging mice produces a non- reversible reconfiguration of spatial maps in proximal CA3, while rarely evoking neural activity. Stimulation of the same neuronal cohort on subsequent days recruits CA3 neurons with increased efficacy but fails to induce further remapping. In contrast, stimulation of 8- week-old (mature) aGCs can reliably activate CA3 cells but produce no alterations in spatial maps. Our results reveal a unique role of young aGCs in remodeling CA3 representations, a potential that can be depleted and is lost with maturation. This ability could contribute to generate orthogonalized downstream codes supporting pattern separation.
影响因子：
8.8
作者：
M. I. Schlesiger;Brittney L. Boublil;J. Hales;J. Leutgeb;S. Leutgeb
通讯作者：
M. I. Schlesiger;Brittney L. Boublil;J. Hales;J. Leutgeb;S. Leutgeb
影响因子：
64.8
作者：
Hainmueller T;Bartos M
通讯作者：
Bartos M