High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals.
High-contrast in vivo visualization of microvessels using novel FeCo/GC magnetic nanocrystals.
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DOI：
10.1002/mrm.22132
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发表时间：
2009-12
影响因子：
3.3
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Lee, Jin Hyung;Sherlock, Sarah P.;Terashima, Masahiro;Kosuge, Hisanori;Suzuki, Yoriyasu;Goodwin, Andrew;Robinson, Joshua;Seo, Won Seok;Liu, Zhuang;Luong, Richard;McConnell, Michael V.;Nishimura, Dwight G.;Dai, Hongjie
FeCo-石墨碳壳纳米晶体是一种新型MRI造影剂，具有前所未有的高金属原子弛豫率（r1 = 97 mM-1 sec-1，r2 = 400 mM-1 sec-1）和多功能能力。虽然传统的钆基对比增强血管造影磁MRI已被证明可用于诊断血管疾病，但其循环时间短和相对较低的灵敏度使得形态学小血管结构（如参与侧支、动脉生成和血管生成血管形成的结构）的高分辨率MRI具有挑战性。在这里，通过将FeCo-石墨碳壳纳米晶体与高分辨率MRI技术相结合，我们证明，使用传统的1.5 T临床MRI系统，可以以高对比度和无创性的方式监测这种低至~100 μm的微血管，达到接近更具侵入性的X射线血管造影的诊断成像标准。初步体外和体内毒性研究结果也显示无毒性迹象。
FeCo-graphitic carbon shell nanocrystals are a novel MRI contrast agent with unprecedented high per-metal-atom-basis relaxivity (r1 = 97 mM−1 sec−1, r2 = 400 mM−1 sec−1) and multifunctional capabilities. While the conventional gadolinium-based contrast-enhanced angiographic magnetic MRI has proven useful for diagnosis of vascular diseases, its short circulation time and relatively low sensitivity render high-resolution MRI of morphologically small vascular structures such as those involved in collateral, arteriogenic, and angiogenic vessel formation challenging. Here, by combining FeCo-graphitic carbon shell nanocrystals with high-resolution MRI technique, we demonstrate that such microvessels down to ~100 μm can be monitored in high contrast and noninvasively using a conventional 1.5-T clinical MRI system, achieving a diagnostic imaging standard approximating that of the more invasive X-ray angiography. Preliminary in vitro and in vivo toxicity study results also show no sign of toxicity.
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DOI：
10.1073/pnas.0707654105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Liu, Zhuang;Davis, Corrine;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
82.9
作者：
Lee, Jae-Hyun;Huh, Yong-Min;Cheon, Jinwoo
通讯作者：
Cheon, Jinwoo
影响因子：
4.4
作者：
Fink, C;Kiessling, F;Delorme, S
通讯作者：
Delorme, S
影响因子：
4.7
作者：
Kiessling, F;Heilmann, M;Semmler, W
通讯作者：
Semmler, W
影响因子：
2.5
作者：
Irarr치zaval, P;Santos, JM;Nishimura, D
通讯作者：
Nishimura, D