Recognition of S-adenosylmethionine by riboswitches.
Recognition of S-adenosylmethionine by riboswitches.
复制标题
DOI：
10.1002/wrna.63
复制
发表时间：
2011-03
影响因子：
7.3
通讯作者：
Batey, Robert T.
中科院分区：
文献类型：
--
作者：
Batey, Robert T.
核糖开关是常见于细菌mRNA的5' - 非翻译区的调控元件，它们结合细胞代谢物以在转录水平或翻译水平指导表达。这些RNA的效应物在化学上是多样的，包括核碱基和核苷、氨基酸、辅因子以及第二信使分子。在过去几年中，许多结构揭示了RNA为这些化合物创造高亲和力和特异性结合口袋的结构方式。对于大多数效应物，存在一类相关的核糖开关。然而，已验证有八类单独的对S - 腺苷甲硫氨酸（SAM）和/或S - 腺苷同型半胱氨酸（SAH）有响应的核糖开关，它们控制硫代谢的各个方面，揭示了识别这些普遍存在的代谢物的多种解决方案。这篇综述着重于结合SAM和SAH的RNA的结构以及它们如何区分这些化合物。
Riboswitches are regulatory elements commonly found in the 5'-untranslated regions of bacterial mRNAs that bind cellular metabolites to direct expression at either the transcriptional or translational level. The effectors of these RNAs are chemically diverse, including nucleobases and nucleosides, amino acids, cofactors, and second messenger molecules. Over the last few years, a number of structures have revealed the architectural means by which RNA creates binding pockets of high affinity and specificity for these compounds. For most effectors, there is a single class of associated riboswitches. However, eight individual classes of S-adenosylmethionine (SAM) and/or S-adenosylhomocysteine (SAH) responsive riboswitches that control various aspects of sulfur metabolism have been validated, revealing a diverse set of solutions to the recognition of these ubiquitous metabolites. This review focuses upon the structures of RNAs that bind SAM and SAH and how they discriminate between these compounds.
登录
查看更多内容
影响因子：
14.9
作者：
Burke, DH;Gold, L
通讯作者：
Gold, L
影响因子：
14.9
作者：
Griffiths-Jones, S;Bateman, A;Eddy, SR
通讯作者：
Eddy, SR
影响因子：
16
作者：
Gusarov, I;Nudler, E
通讯作者：
Nudler, E
影响因子：
64.8
作者：
Batey, RT;Gilbert, SD;Montange, RK
通讯作者：
Montange, RK
代谢物结合核糖开关的分布，机制和结构。
影响因子：
12.3
作者：
Barrick, Jeffrey E;Breaker, Ronald R
通讯作者：
Breaker, Ronald R