Zebrafish as an emerging model to study gonad development

Zebrafish as an emerging model to study gonad development
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斑马鱼作为研究性腺发育的新兴模型

DOI:
10.1016/j.csbj.2020.08.025
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发表时间:
2020-09
期刊:
Comput Struct Biotechnol J
影响因子:
--
通讯作者:
Chen Y.
Chen Y.
中科院分区:
其他
文献类型:
--
作者:
Ye M.;Chen Y.

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斑马鱼(Danio Rerio)因其途径保守性而成为发育生物学和药物遗传学中最受欢迎的模式生物。再加上强大的遗传和转基因工具、透明的胚胎和快速的幼体发育,斑马鱼的研究使许多动态过程的详细细胞分析成为可能。近几十年来,涉及性腺发育过程的细胞和分子机制一直是利用斑马鱼模型进行密集研究的主题。在这篇简短的综述中,我们给出了这些研究的简要概述,并重点介绍了斑马鱼性别决定和性腺发育所涉及的关键基因。
The zebrafish (Danio rerio) has emerged as a popular model organism in developmental biology and pharmacogenetics due to its attribute of pathway conservation. Coupled with the availability of robust genetic and transgenic tools, transparent embryos and rapid larval development, studies of zebrafish allow detailed cellular analysis of many dynamic processes. In recent decades, the cellular and molecular mechanisms involved in the process of gonad development have been the subject of intense research using zebrafish models. In this mini-review, we give a brief overview of these studies, and highlight the essential genes involved in sex determination and gonad development in zebrafish.
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