C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi.
C-type lectin Langerin is a beta-glucan receptor on human Langerhans cells that recognizes opportunistic and pathogenic fungi.
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DOI：
10.1016/j.molimm.2009.12.016
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发表时间：
2010-03
影响因子：
3.6
通讯作者：
Geijtenbeek TB
中科院分区：
文献类型：
--
作者：
de Jong MA;Vriend LE;Theelen B;Taylor ME;Fluitsma D;Boekhout T;Geijtenbeek TB
朗格汉斯细胞（Langerhans cells，LC）位于复层上皮和粘膜组织中，是最早接触病毒、细菌和真菌等入侵病原体的抗原呈递细胞。真菌感染对健康构成威胁，特别是在免疫功能低下的个体中。LC表达对甘露糖、岩藻糖和GlcNAc结构具有特异性的C型凝集素Langerin。关于人类Langerin在真菌感染中的作用知之甚少。我们的数据表明，Langerin与甘露聚糖和β-葡聚糖结构（真菌常见的细胞壁碳水化合物结构）相互作用。我们已经筛选了一个大的面板的真菌识别的人Langerin和，引人注目的是，我们观察到强结合Langerin的各种念珠菌属和酵母属物种和马拉色菌furfur，但非常弱的结合观察到隐球菌gattii和新型隐球菌。值得注意的是，Langerin是LC上的主要真菌受体，因为LC与不同真菌的相互作用被针对Langerin的抗体阻断。Langerin识别真菌细胞壁上存在的甘露糖和β-葡聚糖，并且我们的数据表明Langerin是人类LC上识别致病性和真菌的主要真菌病原体受体。总之，这些数据可以提供更多的了解LC在真菌感染中的作用。
Langerhans cells (LCs) lining the stratified epithelia and mucosal tissues are the first antigen presenting cells to encounter invading pathogens, such as viruses, bacteria and fungi. Fungal infections form a health threat especially in immuno-compromised individuals. LCs express C-type lectin Langerin that has specificity for mannose, fucose and GlcNAc structures. Little is known about the role of human Langerin in fungal infections. Our data show that Langerin interacts with both mannan and β-glucan structures, common cell-wall carbohydrate structures of fungi. We have screened a large panel of fungi for recognition by human Langerin and, strikingly, we observed strong binding of Langerin to a variety of Candida and Saccharomyces species and Malassezia furfur, but very weak binding was observed to Cryptococcus gattii and Cryptococcus neoformans. Notably, Langerin is the primary fungal receptor on LCs, since the interaction of LCs with the different fungi was blocked by antibodies against Langerin. Langerin recognizes both mannose and β-glucans present on fungal cell walls and our data demonstrate that Langerin is the major fungal pathogen receptor on human LCs that recognizes pathogenic and commensal fungi. Together these data may provide more insight in the role of LCs in fungal infections.
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影响因子：
64.5
作者：
Geijtenbeek, TBH;Torensma, R;Figdor, CG
通讯作者：
Figdor, CG
Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
11.8
作者：
Pappas, PG;Perfect, JR;Dismukes, WE
通讯作者：
Dismukes, WE
影响因子：
3.4
作者：
Kozubowski L;Lee SC;Heitman J
通讯作者：
Heitman J