Quantitative Susceptibility Mapping: Translating an Investigative Research Tool into High Volume Clinical Diagnostic Imaging.

Quantitative Susceptibility Mapping: Translating an Investigative Research Tool into High Volume Clinical Diagnostic Imaging.
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DOI:
10.3390/diagnostics12122962
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发表时间:
2022-11-26
期刊:
影响因子:
3.6
通讯作者:
Tamrazi, Benita
Tamrazi, Benita
中科院分区:
医学3区
文献类型:
--
作者:
Borzage, Matthew T.;Doyle, Eamon K.;Liu, Chia-Shang J.;Nelson, Marvin D.;Blueml, Stefan;Wood, John C.;Tamrazi, Benita

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定量磁化率图 (QSM) 是一种基于 MRI 的技术,用于对目标组织进行铁定量。 QSM 为临床医生提供广泛诊断背景下的相关信息,包括镰状细胞病、炎症/脱髓鞘过程和肿瘤。然而,主要 MRI 供应商不提供可供一般使用的 QSM 后处理。这项工作描述了一种与供应商无关的方法,用于将 QSM 分析从研究技术扩展到常规诊断测试。我们提供无缝集成硬件、软件和临床系统所需的详细信息,以便为繁忙的临床放射学工作流程提供 QSM 处理。这种方法可以推广到其他先进的 MRI 采集和分析,具有经过验证的诊断实用性,但无需关键 MR 供应商的支持。
Quantitative susceptibility mapping (QSM) is an MRI-based technique for iron quantification of targeted tissue. QSM provides information relevant to clinicians in a broad range of diagnostic contexts, including sickle cell disease, inflammatory/demyelinating processes, and neoplasms. However, major MRI vendors do not offer QSM post-processing in a form ready for general use. This work describes a vendor-agnostic approach for scaling QSM analysis from a research technique to a routine diagnostic test. We provide the details needed to seamlessly integrate hardware, software, and clinical systems to provide QSM processing for a busy clinical radiology workflow. This approach can be generalized to other advanced MRI acquisitions and analyses with proven diagnostic utility, yet without crucial MR vendor support.
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