Application of Quantitative Magnetic Resonance Imaging in the Diagnosis of Autism in Children.
Application of Quantitative Magnetic Resonance Imaging in the Diagnosis of Autism in Children.
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DOI：
10.3389/fmed.2022.818404
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
探讨定量磁共振成像在儿童自闭症诊断中的应用。60名2-3岁的自闭症儿童和60名年龄和性别匹配的健康儿童参与了这项研究。所有儿童均行头颅MRI常规序列、3D-T1、弥散峰度成像(DKI)、增强T2加权磁共振血管成像(ESWAN)和3D伪连续动脉自旋标记(3D-PCASL)序列扫描。比较两组间各脑区的定量磁化率图(QSM)、脑血流量(CBF)和脑微结构，并进行相关性分析。研究组大鼠额叶、颞叶、海马体、尾状核、黑质、红核的铁含量和脑血流量均低于对照组相应脑区(P<；0.05)。研究组额叶、颞叶、壳核、海马、尾状核、黑质、红核等脑区的平均峰度(MK)、径向峰度(RK)和轴峰度(AK)值均低于对照组相应脑区(P<；0.05)。对照组额叶、颞叶和海马区的平均弥散率(MD)和峰度各向异性分数(FAK)值均低于研究组相应脑区(P<；0.05)。额叶、颞叶和海马区的CBF、QSM和DKI值可以区分ASD儿童(AUC0.5P0.05)，其中多通道技术(QSM、CBF、DKI)的AUC值最高(0.917)，DKI的AUC值最低(0.642)。定量磁共振成像(包括QSM、3D-PCASL和DKI)可以发现自闭症儿童铁含量、脑血流和脑微结构的异常，多模式技术(QSM、CBF、DKI)可作为首选的影像诊断技术。[http://www.chictr.org.cn/searchprojen.aspx]，标识[ChiCTR2000029699]。
To explore the application of quantitative magnetic resonance imaging in the diagnosis of autism in children. Sixty autistic children aged 2–3 years and 60 age- and sex-matched healthy children participated in the study. All the children were scanned using head MRI conventional sequences, 3D-T1, diffusion kurtosis imaging (DKI), enhanced T2*- weighted magnetic resonance angiography (ESWAN) and 3D-pseudo continuous Arterial Spin-Labeled (3D-pcASL) sequences. The quantitative susceptibility mapping (QSM), cerebral blood flow (CBF), and brain microstructure of each brain area were compared between the groups, and correlations were analyzed. The iron content and cerebral blood flow in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, substantia nigra, and red nucleus of the study group were lower than those in the corresponding brain areas of the control group (P < 0.05). The mean kurtosis (MK), radial kurtosis (RK), and axial kurtosis (AK) values of the frontal lobe, temporal lobe, putamen, hippocampus, caudate nucleus, substantia nigra, and red nucleus in the study group were lower than those of the corresponding brain areas in the control group (P < 0.05). The mean diffusivity (MD) and fractional anisotropy of kurtosis (FAK) values of the frontal lobe, temporal lobe and hippocampus in the control group were lower than those in the corresponding brain areas in the study group (P < 0.05). The values of CBF, QSM, and DKI in frontal lobe, temporal lobe and hippocampus could distinguish ASD children (AUC > 0.5, P < 0.05), among which multimodal technology (QSM, CBF, DKI) had the highest AUC (0.917) and DKI had the lowest AUC (0.642). Quantitative magnetic resonance imaging (including QSM, 3D-pcASL, and DKI) can detect abnormalities in the iron content, cerebral blood flow and brain microstructure in young autistic children, multimodal technology (QSM, CBF, DKI) could be considered as the first choice of imaging diagnostic technology. [http://www.chictr.org.cn/searchprojen.aspx], identifier [ChiCTR2000029699].
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DOI：
10.1002/jmri.27019
发表时间：
2020-12
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Andica C;Kamagata K;Hatano T;Saito Y;Ogaki K;Hattori N;Aoki S
通讯作者：
Aoki S
影响因子：
4.4
作者：
Azuma, Minako;Hirai, Toshinori;Wang, Yi
通讯作者：
Wang, Yi
精神分裂症的额神经代谢产物变化及其与认知控制的关联：系统评价。
影响因子：
8.2
作者：
Dixon BJ;Kumar J;Danielmeier C
通讯作者：
Danielmeier C
影响因子：
3.4
作者：
Bedini, Marco;Baldauf, Daniel
通讯作者：
Baldauf, Daniel
影响因子：
3.5
作者：
Boulouis, G.;Dangouloff-Ros, V.;Brunelle, F.
通讯作者：
Brunelle, F.