How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy.
How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy.
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DOI：
10.1007/s10555-023-10124-z
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发表时间：
2023-12
期刊：
影响因子：
--
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文献类型：
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已知循环肿瘤细胞（CTC）是转移性复发的预后，并且在患者中作为孤立细胞或细胞簇检测。循环肿瘤细胞簇（CTC簇）已经在临床上观察了几十年，并且与孤立的CTC相比具有显著更高的转移潜力。最近的研究表明，CTC簇生物学在循环中的侵袭和存活方面存在明显差异。然而，关于传播，休眠和苏醒的差异需要更多的调查相比，孤立的CTC。在这里，我们回顾了CTC簇的研究现状，并考虑其临床意义。此外，我们讨论了集体入侵的概念，CTC集群和分子证据，集群生存循环相比，孤立的CTC。分子之间的差异孤立和集群CTC在休眠和苏醒程序也将进行讨论。我们还强调了未来的发展方向，以促进我们目前对CTC簇生物学的理解。
Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC clusters) have been observed clinically for decades and are of significantly higher metastatic potential compared to solitary CTCs. Recent studies suggest distinct differences in CTC cluster biology regarding invasion and survival in circulation. However, differences regarding dissemination, dormancy, and reawakening require more investigations compared to solitary CTCs. Here, we review the current state of CTC cluster research and consider their clinical significance. In addition, we discuss the concept of collective invasion by CTC clusters and molecular evidence as to how cluster survival in circulation compares to that of solitary CTCs. Molecular differences between solitary and clustered CTCs during dormancy and reawakening programs will also be discussed. We also highlight future directions to advance our current understanding of CTC cluster biology.
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影响因子：
11.2
作者：
Barkan D;Kleinman H;Simmons JL;Asmussen H;Kamaraju AK;Hoenorhoff MJ;Liu ZY;Costes SV;Cho EH;Lockett S;Khanna C;Chambers AF;Green JE
通讯作者：
Green JE
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
EMT亚型影响上皮可塑性和细胞迁移模式。
影响因子：
11.8
作者：
Aiello NM;Maddipati R;Norgard RJ;Balli D;Li J;Yuan S;Yamazoe T;Black T;Sahmoud A;Furth EE;Bar-Sagi D;Stanger BZ
通讯作者：
Stanger BZ
影响因子：
6.9
作者：
Cieply, Benjamin;Koontz, Colton;Frisch, Steven M.
通讯作者：
Frisch, Steven M.
影响因子：
64.5
作者：
Cheung KJ;Gabrielson E;Werb Z;Ewald AJ
通讯作者：
Ewald AJ