Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.
Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.
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内侧前额叶皮质中的脑源性神经营养因子-TrkB信号在神经损伤后的快感缺失样表型中发挥作用
DOI：
10.1007/s00406-018-0909-z
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发表时间：
2020-03
影响因子：
4.7
通讯作者：
Luo A
中科院分区：
文献类型：
--
作者：
Fang X;Yang C;Li S;Zhan G;Zhang J;Huang N;Du X;Xu H;Hashimoto K;Luo A
尽管包括快感缺失(即快感丧失)在内的抑郁症状经常伴随着疼痛，但人们对导致痛性快感缺失个体差异的危险因素知之甚少。在这项研究中，我们研究了脑源性神经营养因子(BDNF)及其受体原肌球蛋白受体激酶B(TrkB)的信号是否在神经病理性疼痛诱导的快感缺失的发展中起到了个体差异的作用。大鼠随机接受备用神经结扎术(SNI)或假手术。SNI大鼠根据蔗糖偏好试验结果分为两组。与非快感缺乏型大鼠和假手术大鼠相比，快感缺乏型大鼠的内侧前额叶皮质(MPFC)内脑源性神经营养因子的表达水平较低。与之相比，快感缺乏型大鼠伏隔核(NAC)内脑源性神经营养因子的组织表达水平高于非快感缺乏型大鼠和假手术组。此外，与假手术组相比，具有或不具有快感缺乏症表型的两组大鼠的海马区、L2-5脊髓、肌肉和肝脏中BDNF的组织水平都较低。单次注射7，8-二羟基黄酮(10 mg/kg，TrkB激动剂)，而不注射ANA-12(0.5 mg/kg，TrkB拮抗剂)，可改善快感缺乏型大鼠mPFC的蔗糖偏好降低和BDNF-TrkB信号转导。这些结果表明，mPFC中BDNF-TrkB信号的减少可能参与了神经病理性痛性快感缺失的发生，TrkB激动剂可能是治疗痛性快感缺失的潜在药物。
Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-receptor-kinase B (TrkB) contribute to individual differences in the development of neuropathic pain-induced anhedonia. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups based on the results of a sucrose preference test. Rats with anhedonia-like phenotype displayed lower tissue levels of BDNF in the medial prefrontal cortex (mPFC) compared with rats without anhedonia-like phenotype and sham-operated rats. In contrast, tissue levels of BDNF in the nucleus accumbens (NAc) of rats with an anhedonia-like phenotype were higher compared with those of rats without anhedonia-like phenotype and sham-operated rats. Furthermore, tissue levels of BDNF in the hippocampus, L2–5 spinal cord, muscle, and liver from both rats with or without anhedonia-like phenotype were lower compared with those of sham-operated rats. A single injection of 7,8-dihydroxyflavone (10 mg/kg; TrkB agonist), but not ANA-12 (0.5 mg/kg; TrkB antagonist), ameliorated reduced sucrose preference and reduced BDNF-TrkB signaling in the mPFC in the rats with anhedonia-like phenotype. These findings suggest that reduced BDNF-TrkB signaling in the mPFC might contribute to neuropathic pain-induced anhedonia, and that TrkB agonists could be potential therapeutic drugs for pain-induced anhedonia.
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影响因子：
4.8
作者：
Hurtado E;Cilleros V;Nadal L;Simó A;Obis T;Garcia N;Santafé MM;Tomàs M;Halievski K;Jordan CL;Lanuza MA;Tomàs J
通讯作者：
Tomàs J
影响因子：
4.6
作者：
Ma M;Ren Q;Yang C;Zhang JC;Yao W;Dong C;Ohgi Y;Futamura T;Hashimoto K
通讯作者：
Hashimoto K
DOI：
10.1093/ijnp/pyw089
发表时间：
2017-03-01
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Dong C;Zhang JC;Yao W;Ren Q;Ma M;Yang C;Chaki S;Hashimoto K
通讯作者：
Hashimoto K
Anhedonia预测，选择性5-羟色胺再摄取抑制剂耐药性抑郁症的青年的恢复较差。
DOI：
10.1016/j.jaac.2012.01.011
发表时间：
2012-04
影响因子：
13.3
作者：
McMakin DL;Olino TM;Porta G;Dietz LJ;Emslie G;Clarke G;Wagner KD;Asarnow JR;Ryan ND;Birmaher B;Shamseddeen W;Mayes T;Kennard B;Spirito A;Keller M;Lynch FL;Dickerson JF;Brent DA
通讯作者：
Brent DA
Brexprazole和氟西汀组合对抑郁样行为和炎症后小鼠的树突变化的抗抑郁药作用。
影响因子：
3.4
作者：
Ma M;Ren Q;Yang C;Zhang JC;Yao W;Dong C;Ohgi Y;Futamura T;Hashimoto K
通讯作者：
Hashimoto K