Paternal Mitochondrial Transmission in Intra-Species Caenorhabditis briggsae Hybrids.

Paternal Mitochondrial Transmission in Intra-Species Caenorhabditis briggsae Hybrids.
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DOI:
10.1093/molbev/msw192
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发表时间:
2016-12
影响因子:
10.7
通讯作者:
Estes S
Estes S
中科院分区:
生物学1区
文献类型:
--
作者:
Ross JA;Howe DK;Coleman-Hulbert A;Denver DR;Estes S

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为了研究胞质-核的遗传相互作用在线虫的小杆线虫Briggsae,我们的三个实验室独立创建了38个种内的细胞质-核杂交(胞质杂种)线。虽然杂交设计结合了母本核基因型与父本核基因型,八行(21%)意外地包含父本核基因型。所有八个都有两个遗传相关菌株之一的共同祖先。这种对父系线粒体传递的意想不到的平行观察,考虑到我们创造胞质杂种的意图,是不希望的,提供了一个偶然的实验模型和框架来研究单亲线粒体遗传的分子和进化基础。
To study mitochondrial–nuclear genetic interactions in the nematode Caenorhabditis briggsae, our three laboratories independently created 38 intra-species cytoplasmic–nuclear hybrid (cybrid) lines. Although the cross design combines maternal mitotypes with paternal nuclear genotypes, eight lines (21%) unexpectedly contained paternal mitotypes. All eight share in common ancestry of one of two genetically related strains. This unexpected parallel observation of paternal mitochondrial transmission, undesirable given our intent of creating cybrids, provides a serendipitous experimental model and framework to study the molecular and evolutionary basis of uniparental mitochondrial inheritance.
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