Lipid Metabolism in Oncology: Why It Matters, How to Research, and How to Treat.
Lipid Metabolism in Oncology: Why It Matters, How to Research, and How to Treat.
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肿瘤学中的脂代谢：为什么重要，如何研究，以及如何治疗。
DOI：
10.3390/cancers13030474
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发表时间：
2021-01-26
期刊：
影响因子：
5.2
通讯作者：
Koike K
中科院分区：
文献类型：
--
作者：
Matsushita Y;Nakagawa H;Koike K
代谢重编程作为癌症的标志越来越受到关注。然而，由于技术问题，脂质代谢一直难以分析。近年来，脂质组学技术（如质谱法）取得了进展，使我们能够分析癌症的详细脂质谱。此外，已经清楚的是，脂质代谢的变化在癌症与周围微环境之间的相互作用中也起重要作用。本文综述了脂质重程序代谢及脂质组学技术在肿瘤研究中的最新进展。我们体内的脂质主要由脂肪酸、甘油三酯、鞘脂、磷脂和胆固醇组成，在细胞水平上起着重要作用。除了作为能量来源和生物膜的结构组分之外，几种类型的脂质还充当信号分子或第二信使。代谢重编程已被认为是癌症的标志，但与葡萄糖或谷氨酰胺代谢相比，癌症中脂质代谢的变化受到的关注较少。然而，最近基于质谱和色谱的脂质组学技术的创新增加了我们对脂质在癌症中的作用的理解。脂质代谢的改变，即所谓的“脂质代谢重编程”，可以影响细胞功能，包括细胞周期、增殖、生长和分化，导致致癌。此外，已知癌细胞和相邻免疫细胞之间通过改变脂质代谢的相互作用支持肿瘤生长和进展。癌症特异性脂质代谢的表征可用于确定癌症治疗的新代谢靶点，事实上，目前正在进行几项临床试验。因此，我们讨论了脂质代谢在癌症生物学中的作用的最新发现，并介绍了脂质组学技术的最新进展，重点是它们在癌症研究中的应用。
Metabolic reprogramming is gaining attentions as a hallmark of cancers. However, lipid metabolism has been difficult to analyze due to technical problems. In recent years, lipidomics techniques such as mass spectrometry have advanced and allowed us to analyze detailed lipid profiles of cancers. Moreover, it has become clear that changes in lipid metabolism also play an important role in the interaction between the cancers and the surrounding microenvironment. This review summarizes the latest research progress of reprogrammed lipid metabolism and also lipidomics technologies applied in cancer research. Lipids in our body, which are mainly composed of fatty acids, triacylglycerides, sphingolipids, phospholipids, and cholesterol, play important roles at the cellular level. In addition to being energy sources and structural components of biological membranes, several types of lipids serve as signaling molecules or secondary messengers. Metabolic reprogramming has been recognized as a hallmark of cancer, but changes in lipid metabolism in cancer have received less attention compared to glucose or glutamine metabolism. However, recent innovations in mass spectrometry- and chromatography-based lipidomics technologies have increased our understanding of the role of lipids in cancer. Changes in lipid metabolism, so-called “lipid metabolic reprogramming”, can affect cellular functions including the cell cycle, proliferation, growth, and differentiation, leading to carcinogenesis. Moreover, interactions between cancer cells and adjacent immune cells through altered lipid metabolism are known to support tumor growth and progression. Characterization of cancer-specific lipid metabolism can be used to identify novel metabolic targets for cancer treatment, and indeed, several clinical trials are currently underway. Thus, we discuss the latest findings on the roles of lipid metabolism in cancer biology and introduce current advances in lipidomics technologies, focusing on their applications in cancer research.
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影响因子：
16.1
作者：
Butler LM;Perone Y;Dehairs J;Lupien LE;de Laat V;Talebi A;Loda M;Kinlaw WB;Swinnen JV
通讯作者：
Swinnen JV
DOI：
10.1073/pnas.1700677114
发表时间：
2017-03-28
影响因子：
11.1
作者：
Banerjee, Shibdas;Zare, Richard N.;Sonn, Geoffrey A.
通讯作者：
Sonn, Geoffrey A.
影响因子：
29
作者：
Cheng, Xiang;Geng, Feng;Guo, Deliang
通讯作者：
Guo, Deliang
溶血磷脂酰胆碱酰基转移酶2介导的脂质液滴生产支持结直肠癌的化学耐药性。
影响因子：
16.6
作者：
Cotte AK;Aires V;Fredon M;Limagne E;Derangère V;Thibaudin M;Humblin E;Scagliarini A;de Barros JP;Hillon P;Ghiringhelli F;Delmas D
通讯作者：
Delmas D
影响因子：
7.2
作者：
Al-Khami, Amir A.;Zheng, Liqin;Ochoa, Augusto C.
通讯作者：
Ochoa, Augusto C.