Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.
Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.
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DOI：
10.1016/j.celrep.2013.06.013
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发表时间：
2013-07-11
期刊：
影响因子：
8.8
通讯作者：
Gurova KV
中科院分区：
文献类型：
--
作者：
Garcia H;Miecznikowski JC;Safina A;Commane M;Ruusulehto A;Kilpinen S;Leach RW;Attwood K;Li Y;Degan S;Omilian AR;Guryanova O;Papantonopoulou O;Wang J;Buck M;Liu S;Morrison C;Gurova KV
促进染色质转录（FACT）复合物参与转录、复制和DNA修复过程中的染色质重塑。FACT以前被认为是普遍表达的，与任何疾病无关。然而，我们发现FACT是一类新型抗癌化合物的靶标，并且除了未分化的干细胞和干细胞样细胞外，在成年哺乳动物组织的正常细胞中不表达。在这里，我们发现FACT表达与低分化侵袭性癌症和低总生存率密切相关。此外，发现FACT在体外转化过程中上调，并且是驱动转化所必需的，但不完全足够。FACT还促进了已建立的肿瘤细胞的存活和生长。染色质结合FACT的全基因组图谱表明，FACT在癌症中的作用可能涉及刺激增殖、抑制细胞死亡和分化以及调节细胞应激反应的基因的选择性染色质重塑。
The Facilitates Chromatin Transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a novel class of anti-cancer compounds and is not expressed in normal cells of adult mammalian tissues, except for undifferentiated and stem-like cells. Here, we show that FACT expression is strongly associated with poorly differentiated aggressive cancers with poor overall survival. In addition, FACT was found to be upregulated during in vitro transformation and to be necessary, but not fully sufficient, to drive transformation. FACT also promoted survival and growth of established tumor cells. Genome-wide mapping of chromatin-bound FACT indicated that FACT’s role in cancer likely involves selective chromatin remodeling of genes that stimulate proliferation, inhibit cell death and differentiation, and regulate cellular stress responses.
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影响因子：
3
作者：
Feng X;Grossman R;Stein L
通讯作者：
Stein L
影响因子：
23.9
作者：
Pardo M;Lang B;Yu L;Prosser H;Bradley A;Babu MM;Choudhary J
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Choudhary J
DOI：
10.1016/j.bbagrm.2011.07.009
发表时间：
2012-03
影响因子：
4.7
作者：
Formosa, Tim
通讯作者：
Formosa, Tim
影响因子：
4.8
作者：
Li, YP;Keller, DM;Lu, H
通讯作者：
Lu, H
影响因子：
11.4
作者：
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通讯作者：
Zomerdijk, Joost C. B. M.