Age-related neurochemical changes in the rhesus macaque cochlear nucleus.
Age-related neurochemical changes in the rhesus macaque cochlear nucleus.
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DOI：
10.1002/cne.23479
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发表时间：
2014-05-01
影响因子：
2.5
通讯作者：
Recanzone, Gregg H.
中科院分区：
文献类型：
--
作者：
Gray, Daniel T.;Engle, James R.;Recanzone, Gregg H.
中枢听觉系统内各种蛋白质表达的神经化学变化与自然衰老有关。这些变化可以部分补偿听觉灵敏度的损失所产生的两种现象的老化听觉系统：耳蜗组织病理学和中枢听觉神经元的兴奋性增加。最近在猕猴中的研究揭示了年龄相关的变化，在下丘和上级橄榄复合体内的烟酰胺腺嘌呤二核苷酸磷酸（NADPH）-黄递酶（NADPH d）和小白蛋白（PV）阳性细胞的密度。耳蜗核（CN），这是第一个中央听觉核，仍然没有研究。由于CN参与了听觉脑干反应（ABR）的产生，并接受耳蜗的直接神经支配，因此它是比较这些神经化学变化与衰老听觉系统的生理和外周变化之间关系的理想核团。我们使用体视学采样计算密度的NADPHd和PV反应神经元内的三个分区的CN在中年和老年恒河猴。这些值与ABR特性和耳蜗组织病理学的回归分析揭示了这些细胞类型和老化听觉系统的变化特征之间的关系。我们的研究结果表明，NADPHd的表达确实随着年龄的变化，在一个特定的细分的CN，但PV不。相反，PV表达与ABR振幅和耳蜗外毛细胞丢失相关，但NADPH d没有。这些结果表明，NADPHd和PV可能参与了不同的老化听觉系统的代偿努力。
Neurochemical changes in the expression of various proteins within the central auditory system have been associated with natural aging. These changes may compensate in part for the loss of auditory sensitivity arising from two phenomena of the aging auditory system: cochlear histopathologies and increased excitability of central auditory neurons. Recent studies in the macaque monkey have revealed age-related changes in the density of nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase (NADPHd) and parvalbumin (PV)-positive cells within the inferior colliculus and superior olivary complex. The cochlear nucleus (CN), which is the first central auditory nucleus, remains unstudied. Since the CN participates in the generation of the auditory brainstem response (ABR) and receives direct innervation from the cochlea, it serves as an ideal nucleus to compare the relationship between these neurochemical changes and the physiological and peripheral changes of the aging auditory system. We used stereological sampling to calculate the densities of NADPHd and PV reactive neurons within the three subdivisions of the CN in middle-aged and aged rhesus macaques. Regression analyses of these values with ABR properties and cochlear histopathologies revealed relationships between these cell types and the changing characteristics of the aging auditory system. Our results indicate that NADPHd expression does change with age in a specific subdivision of the CN, but PV does not. Conversely, PV expression correlated with ABR amplitudes and outer hair cell loss in the cochlea, but NADPHd did not. These results indicate that NADPHd and PV may take part in distinct compensatory efforts of the aging auditory system.
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影响因子：
1.9
作者：
BENNETT, CL;DAVIS, RT;MILLER, JM
通讯作者：
MILLER, JM
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH
影响因子：
3.3
作者：
Caspary, DM;Holder, TM;Naritoku, DK
通讯作者：
Naritoku, DK
影响因子：
2.8
作者：
Fowler, Cynthia G.;Chiasson, Kirstin Beach;Leslie, Tami Hanson;Thomas, Denise;Beasley, T. Mark;Kemnitz, Joseph W.;Weindruch, Richard
通讯作者：
Weindruch, Richard
DOI：
10.1073/pnas.87.2.682
发表时间：
1990-01-01
影响因子：
11.1
作者：
BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH