Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later.
Auditory function in rhesus monkeys: effects of aging and caloric restriction in the Wisconsin monkeys five years later.
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DOI：
10.1016/j.heares.2010.01.006
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发表时间：
2010-03
期刊：
影响因子：
2.8
通讯作者：
Weindruch, Richard
中科院分区：
文献类型：
--
作者：
Fowler, Cynthia G.;Chiasson, Kirstin Beach;Leslie, Tami Hanson;Thomas, Denise;Beasley, T. Mark;Kemnitz, Joseph W.;Weindruch, Richard
关键词：
热量限制（CR）减缓了许多物种的衰老，并保护一些动物免受与年龄相关的听力损失（ARHL），但对人类的影响尚不清楚。由于恒河猴是长寿的灵长类动物，在系统发育上比其他研究动物更接近人类，因此它们为研究CR对衰老和ARHL的影响提供了更好的模型。受试者来自55只年龄在15-28岁之间的恒河猴，这些恒河猴参加了威斯康星州的CR和衰老研究，时间为8-13.5年。在2211-8837 Hz范围内获得了f2频率的失真产物耳声发射（DPOAE），以及点击声和8、16和32 kHz音调爆发的听觉脑干反应（ABR）阈值。DPOAE水平以大约1 dB/年的速度线性下降，但在最老的猴子中，频率最高的速度增加了一倍。饮食状况和性别之间没有相互作用。ABR对咔哒声和音调爆发的阈值随着年龄的增长而增加。在8千赫的刺激下，饮食的阈值具有临界意义，而热量限制的猴子的阈值较低。由于恒河猴的最长寿命为40年，CR的全部益处可能尚未实现。
Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studying the effects of CR in aging and ARHL. Subjects were from the pool of 55 rhesus monkeys aged 15–28 years who had been in the Wisconsin study on CR and aging for 8–13.5 years. Distortion product otoacoustic emissions (DPOAE) with f2 frequencies from 2211–8837 Hz and auditory brainstem response (ABR) thresholds from clicks and 8, 16, and 32 kHz tone bursts were obtained. DPOAE levels declined linearly at approximately 1 dB/year, but that rate doubled for the highest frequencies in the oldest monkeys. There were no interactions for diet condition or sex. ABR thresholds to clicks and tone bursts showed increases with aging. Borderline significance was shown for diet in the thresholds at 8 kHz stimuli, with monkeys on caloric restriction having lower thresholds. Because the rhesus monkeys have a maximum longevity of 40 years, the full benefits of CR may not yet be realized.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
1.9
作者：
BENNETT, CL;DAVIS, RT;MILLER, JM
通讯作者：
MILLER, JM
影响因子：
2.8
作者：
Frisina, Robert D.;Walton, Joseph P.
通讯作者：
Walton, Joseph P.
DOI：
10.1111/j.1532-5415.1989.tb05870.x
发表时间：
1989-02-01
影响因子：
6.3
作者：
BESS, FH;LICHTENSTEIN, MJ;NELSON, E
通讯作者：
NELSON, E
影响因子：
1.4
作者：
JOHNSSON, LG;HAWKINS, JE
通讯作者：
HAWKINS, JE