Oxidative Stress in Cancer Cell Metabolism.
Oxidative Stress in Cancer Cell Metabolism.
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DOI：
10.3390/antiox10050642
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发表时间：
2021-04-22
期刊：
影响因子：
--
通讯作者：
Kumar D
中科院分区：
文献类型：
--
作者：
Arfin S;Jha NK;Jha SK;Kesari KK;Ruokolainen J;Roychoudhury S;Rathi B;Kumar D
活性氧物种(ROS)在调节正常的细胞过程中起着重要作用，而ROS的失控会导致包括癌症在内的人类疾病状态的发展。一些研究发现，ROS的产生增加了，它激活了促肿瘤信号，增强了细胞的存活和增殖，并导致了DNA损伤和遗传不稳定。然而，更高的ROS水平被发现通过启动氧化应激诱导的肿瘤细胞死亡来促进抗肿瘤信号。肿瘤细胞形成一种机制，通过表达高水平的抗氧化蛋白来解毒，同时保持促肿瘤信号和对凋亡的抵抗，从而适应高ROS。因此，ROS操作可能成为癌症治疗的潜在靶点，因为与正常细胞相比，癌细胞呈现出一种改变的氧化还原平衡。本文就肿瘤细胞内ROS的产生和来源、ROS相关的信号通路、抗氧化防御系统对ROS的调节以及ROS生成增加在肿瘤进展中的作用作一综述。它将提供一个洞察如何在癌症治疗期间操纵促肿瘤和抗肿瘤的ROS信号通路。
Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts. In this review, we aim to provide an overview of the generation and sources of ROS within tumor cells, ROS-associated signaling pathways, their regulation by antioxidant defense systems, as well as the effect of elevated ROS production in tumor progression. It will provide an insight into how pro- and anti-tumorigenic ROS signaling pathways could be manipulated during the treatment of cancer.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
5.6
作者：
Bolisetty S;Jaimes EA
通讯作者：
Jaimes EA
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
3.5
作者：
BATES, DA;WINTERBOURN, CC
通讯作者：
WINTERBOURN, CC