Mitochondria and reactive oxygen species: physiology and pathophysiology.
Mitochondria and reactive oxygen species: physiology and pathophysiology.
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DOI：
10.3390/ijms14036306
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发表时间：
2013-03-19
影响因子：
5.6
通讯作者：
Jaimes EA
中科院分区：
文献类型：
--
作者：
Bolisetty S;Jaimes EA
我们呼吸的空气中含有近21%的氧气，其中大部分在呼吸过程中被线粒体利用。虽然我们离不开它，但它被认为是有氧生物的祸害，因为线粒体和其他细胞隔室会产生活性氧和氮代谢物。然而，当这些物种被证明通过改变信号通路来调节细胞反应时，这一教条受到了挑战。事实上，自从发现反应性物质在免疫功能和信号转导中的二分作用以来，该领域的研究以指数速度增长，并开始追求相关机制。由于大量的评论文章目前的反应性物种介导的细胞死亡，我们一直专注于新兴的新途径，如自噬，信号和线粒体网络的维护。尽管它在几个过程中的作用，增加反应性物种的产生已与过多的疾病的起源和发病机制。虽然人们很容易推测抗氧化治疗可以预防这些疾病，但越来越多的证据表明这可能不是真的。这进一步支持了我们的信念，即这些活性物质在维持细胞和组织的稳态中起着重要作用。
The air that we breathe contains nearly 21% oxygen, most of which is utilized by mitochondria during respiration. While we cannot live without it, it was perceived as a bane to aerobic organisms due to the generation of reactive oxygen and nitrogen metabolites by mitochondria and other cellular compartments. However, this dogma was challenged when these species were demonstrated to modulate cellular responses through altering signaling pathways. In fact, since this discovery of a dichotomous role of reactive species in immune function and signal transduction, research in this field grew at an exponential pace and the pursuit for mechanisms involved began. Due to a significant number of review articles present on the reactive species mediated cell death, we have focused on emerging novel pathways such as autophagy, signaling and maintenance of the mitochondrial network. Despite its role in several processes, increased reactive species generation has been associated with the origin and pathogenesis of a plethora of diseases. While it is tempting to speculate that anti-oxidant therapy would protect against these disorders, growing evidence suggests that this may not be true. This further supports our belief that these reactive species play a fundamental role in maintenance of cellular and tissue homeostasis.
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DOI：
10.2174/138955708786369582
发表时间：
2008-11
期刊：
Mini reviews in medicinal chemistry
影响因子：
--
作者：
Aliev G;Obrenovich ME;Reddy VP;Shenk JC;Moreira PI;Nunomura A;Zhu X;Smith MA;Perry G
通讯作者：
Perry G
影响因子：
29
作者：
Baker RG;Hayden MS;Ghosh S
通讯作者：
Ghosh S
影响因子：
11.4
作者：
Barsoum, Mark J.;Yuan, Hua;Bossy-Wetzel, Ella
通讯作者：
Bossy-Wetzel, Ella
影响因子：
4
作者：
Aravindan, Natarajan;Mohan, Sumathy;Natarajan, Mohan
通讯作者：
Natarajan, Mohan
影响因子：
15.9
作者：
BABIOR, BM;KIPNES, RS;CURNUTTE, JT
通讯作者：
CURNUTTE, JT