Genetic Mechanisms and Aberrant Gene Expression during the Development of Gastric Intestinal Metaplasia and Adenocarcinoma.
Genetic Mechanisms and Aberrant Gene Expression during the Development of Gastric Intestinal Metaplasia and Adenocarcinoma.
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DOI：
10.2174/138920207783406460
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发表时间：
2007-09
期刊：
影响因子：
2.6
通讯作者：
O'Morain C
中科院分区：
文献类型：
--
作者：
Holmes K;Egan B;Swan N;O'Morain C
胃腺癌是通过一系列称为科雷亚级联的分子事件发生的，通常会持续多年。淋病，通常由细菌H感染引起。幽门螺杆菌是导致胃癌的级联反应的第一步;然而，并非所有胃炎病例都沿着这一致癌途径进展。尽管最近的抗生素干预H。幽门螺杆菌感染，胃腺癌仍然是世界范围内癌症死亡的第二大常见原因。肠上皮化生是继胃炎之后沿着致癌序列的下一步，被认为是胃癌的前驱病变;然而，并非所有肠上皮化生患者都会发展为腺癌，并且对触发肠上皮化生进展为腺癌的分子和遗传事件知之甚少。本文就胃癌及其前病变肠上皮化生的遗传学研究进展作一综述。全基因组微阵列分析、免疫组化分析和DNA甲基化分析等技术的应用使人们能够深入了解肠上皮化生中发生的一些事件，这些事件可能与癌变有关。围绕这种病变的发展以及在许多情况下它如何发展成恶性状态，仍然有很多东西有待发现。
Gastric adenocarcinoma occurs via a sequence of molecular events known as the Correa’s Cascade which often progresses over many years. Gastritis, typically caused by infection with the bacterium H. pylori, is the first step of the cascade that results in gastric cancer; however, not all cases of gastritis progress along this carcinogenic route. Despite recent antibiotic intervention of H. pylori infections, gastric adenocarcinoma remains the second most common cause of cancer deaths worldwide. Intestinal metaplasia is the next step along the carcinogenic sequence after gastritis and is considered to be a precursor lesion for gastric cancer; however, not all patients with intestinal metaplasia develop adenocarcinoma and little is known about the molecular and genetic events that trigger the progression of intestinal metaplasia into adenocarcinoma. This review aims to highlight the progress to date in the genetic events involved in intestinal-type gastric adenocarcinoma and its precursor lesion, intestinal metaplasia. The use of technologies such as whole genome microarray analysis, immunohistochemical analysis and DNA methylation analysis has allowed an insight into some of the events which occur in intestinal metaplasia and may be involved in carcinogenesis. There is still much that is yet to be discovered surrounding the development of this lesion and how, in many cases, it develops into a state of malignancy.
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