Small molecule inducers of actinobacteria natural product biosynthesis.
Small molecule inducers of actinobacteria natural product biosynthesis.
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DOI：
10.1093/jimb/kuad019
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发表时间：
2023-02-17
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
放线菌是一个庞大而多样的细菌群，已知其产生广泛的次级代谢产物，其中许多具有重要的生物活性，包括抗生素、抗癌剂和免疫抑制剂。这些化合物的生物合成通常受到高度调节，许多天然产物（NP）在实验室环境中以非常低的水平产生。环境因素，如小分子激发子，可以诱导次生代谢产物的产生。具体而言，它们可以增加已知NP的滴度，并能够发现通常以不可检测水平产生的新型NP。这些激发子可以是NP，包括抗生素或激素，或合成化合物。近年来，人们对使用小分子诱导剂诱导放线菌产生次级代谢产物的兴趣越来越大，特别是对于从“沉默”生物合成基因簇中发现NP。本文综述了放线菌次级代谢产物的诱导分子，并介绍了其诱导机制。本文综述了迄今为止所描述的放线菌天然产物的化学诱导剂及其诱导机制。化学物质，包括天然产物抗生素和激素，能够诱导放线菌产生天然产物。
Actinobacteria are a large and diverse group of bacteria that are known to produce a wide range of secondary metabolites, many of which have important biological activities, including antibiotics, anti-cancer agents, and immunosuppressants. The biosynthesis of these compounds is often highly regulated with many natural products (NPs) being produced at very low levels in laboratory settings. Environmental factors, such as small molecule elicitors, can induce the production of secondary metabolites. Specifically, they can increase titers of known NPs as well as enabling discovery of novel NPs typically produced at undetectable levels. These elicitors can be NPs, including antibiotics or hormones, or synthetic compounds. In recent years, there has been a growing interest in the use of small molecule elicitors to induce the production of secondary metabolites from actinobacteria, especially for the discovery of NPs from “silent” biosynthetic gene clusters. This review aims to highlight classes of molecules that induce secondary metabolite production in actinobacteria and to describe the potential mechanisms of induction. This review describes chemical elicitors of actinobacteria natural products described to date and the proposed mechanisms of induction. Chemicals, including natural product antibiotics and hormones, are capable of inducing production of natural products in actinobacteria.
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影响因子：
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DOI：
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发表时间：
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影响因子：
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