Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels.
Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels.
复制标题
DOI：
10.1186/ar4552
复制
发表时间：
2014-04-25
影响因子：
4.9
通讯作者：
Rigby WF
中科院分区：
文献类型：
--
作者：
Jones JD;Hamilton BJ;Challener GJ;de Brum-Fernandes AJ;Cossette P;Liang P;Masetto A;Ménard HA;Carrier N;Boyle DL;Rosengren S;Boire G;Rigby WF
我们假设B细胞趋化因子C-X-C基序趋化因子13(CXCL13)的血清水平将描述以体液免疫增强为特征的类风湿性关节炎(RA)患者的亚群。对已确诊的类风湿性关节炎患者(达特茅斯类风湿性关节炎队列)的血清进行CXCL13、类风湿因子(RF)水平、抗核苷酸肽/蛋白抗体(ACPA)和总免疫球蛋白G(Ig G)的分析，其他参数通过图表复习获得。使用舍布鲁克早期未分化多发性关节炎(EUPA)队列样本进行了验证性分析。采用Wilcoxon秩和检验、t检验和Spearman相关分析来确定变量之间的关系。在达特茅斯和舍布鲁克队列中，CXCL13水平在血清阳性相对于血清阴性的RA患者中选择性地升高(P=0.0002和P<；0.0001)，与免疫球蛋白M和IgA RF水平都有很强的相关性(P<；0.0001)。与ACPA滴度(P=0.03和P=0.006)和总免疫球蛋白(P=0.02和P=0.14)的相关性较弱。与年龄、性别、共有表位状态或在队列中包含高敏C反应蛋白(HsCRP)或Sherbrooke队列中是否存在基线侵蚀无关，而与28个关节疾病活动评分(DAS28-CRP)的关系在Dartuss队列中被发现，但在Sherbrooke队列中未见。使用已建立的和早期的RA队列，血清CXCL13水平的显著升高几乎完全存在于血清阳性人群中。CXCL13水平与RF有很强的相关性，而与临床参数(年龄、性别、DAS28-CRP和糜烂)或其他血清标志物(ACPA和IgG)的相关性要么弱得多，要么不存在。血清CXCL13水平升高可以确定血清阳性RA患者的亚群，这些患者的疾病是由RF产生的或对RF产生的反应形成的。
We hypothesized that serum levels of C-X-C motif chemokine 13 (CXCL13), a B-cell chemokine, would delineate a subset of rheumatoid arthritis (RA) patients characterized by increased humoral immunity. Serum from patients with established RA (the Dartmouth RA Cohort) was analyzed for CXCL13, rheumatoid factor (RF) levels, anticitrullinated peptide/protein antibody (ACPA) and total immunoglobulin G (IgG); other parameters were obtained by chart review. A confirmatory analysis was performed using samples from the Sherbrooke Early Undifferentiated PolyArthritis (EUPA) Cohort. The Wilcoxon rank-sum test, a t-test and Spearman’s correlation analysis were utilized to determine relationships between variables. In both the Dartmouth and Sherbrooke cohorts, CXCL13 levels were selectively increased in seropositive relative to seronegative RA patients (P = 0.0002 and P < 0.0001 for the respective cohorts), with a strong correlation to both immunoglobulin M (IgM) and IgA RF levels (P < 0.0001). There was a weaker relationship to ACPA titers (P = 0.03 and P = 0.006, respectively) and total IgG (P = 0.02 and P = 0.14, respectively). No relationship was seen with regard to age, sex, shared epitope status or inclusion high-sensitivity C-reactive protein (hsCRP) in either cohort or regarding the presence of baseline erosions in the Sherbrooke Cohort, whereas a modest relationship with Disease Activity Score in 28 joints CRP (DAS28-CRP) was seen in the Dartmouth cohort but not the Sherbrooke cohort. Using both established and early RA cohorts, marked elevations of serum CXCL13 levels resided nearly completely within the seropositive population. CXCL13 levels exhibited a strong relationship with RF, whereas the association with clinical parameters (age, sex, DAS28-CRP and erosions) or other serologic markers (ACPA and IgG) was either much weaker or absent. Elevated serum CXCL13 levels may identify a subset of seropositive RA patients whose disease is shaped by or responsive to RF production.
登录
查看更多内容
影响因子：
--
作者：
Sellam, Jeremie;Rouanet, Stephanie;Mariette, Xavier
通讯作者：
Mariette, Xavier
影响因子：
64.8
作者：
Ansel, KM;Ngo, VN;Cyster, JG
通讯作者：
Cyster, JG
影响因子：
20.3
作者：
Carlsen, HS;Baekkevold, ES;Brandtzaeg, P
通讯作者：
Brandtzaeg, P
影响因子：
32.4
作者：
Luther, SA;Lopez, T;Cyster, JG
通讯作者：
Cyster, JG
影响因子：
--
作者：
Manzo, Antonio;Vitolo, Barbara;Pitzalis, Costantino
通讯作者：
Pitzalis, Costantino