Hypoxic Microenvironment and Metastatic Bone Disease.
Hypoxic Microenvironment and Metastatic Bone Disease.
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DOI：
10.3390/ijms19113523
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发表时间：
2018-11-09
影响因子：
5.6
通讯作者：
Hiraga T
中科院分区：
文献类型：
--
作者：
Hiraga T
缺氧是实体瘤的常见特征，与转移风险增加和预后不良相关。最近的成像技术显示，骨髓含有一个相当缺氧的微环境。低氧水平激活低氧信号传导途径，如低氧诱导因子，其在转移性播散的关键阶段中发挥关键作用，包括血管生成、上皮-间充质转化、侵袭、癌症干细胞的维持、肿瘤细胞休眠、细胞外囊泡的释放和转移前小生境的产生。缺氧还影响骨细胞，如成骨细胞和破骨细胞，以及免疫细胞，它们也起支持骨转移的发展和进展的作用。特别是，缺氧和相关信号分子被认为是高优先级的治疗靶点，许多候选药物目前正在进行临床前和临床研究。本综述着重于我们目前的知识，考虑到转移癌细胞和骨微环境之间的相互作用，缺氧在癌症转移到骨的潜在作用。还描述了目前针对缺氧的治疗方法。
Hypoxia is a common feature of solid tumors and is associated with an increased risk of metastasis and a poor prognosis. Recent imaging techniques revealed that bone marrow contains a quite hypoxic microenvironment. Low oxygen levels activate hypoxia signaling pathways such as hypoxia-inducible factors, which play critical roles in the key stages of metastatic dissemination including angiogenesis, epithelial-mesenchymal transition, invasion, maintenance of cancer stem cells, tumor cell dormancy, release of extracellular vesicles, and generation of pre-metastatic niches. Hypoxia also affects bone cells, such as osteoblasts and osteoclasts, and immune cells, which also act to support the development and progression of bone metastases. Paradoxically, hypoxia and related signaling molecules are recognized as high-priority therapeutic targets and many candidate drugs are currently under preclinical and clinical investigation. The present review focuses on our current knowledge of the potential roles of hypoxia in cancer metastasis to bone by considering the interaction between metastatic cancer cells and the bone microenvironment. Current therapeutic approaches targeting hypoxia are also described.
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影响因子：
3.7
作者：
Bondareva A;Downey CM;Ayres F;Liu W;Boyd SK;Hallgrimsson B;Jirik FR
通讯作者：
Jirik FR
影响因子：
4
作者：
de Prati, Alessandra Carcereri;Butturini, Elena;Mariotto, Sofia
通讯作者：
Mariotto, Sofia
影响因子：
6.2
作者：
Croset, Martine;Goehrig, Delphine;Clezardin, Philippe
通讯作者：
Clezardin, Philippe
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
11.5
作者：
Coleman, Robert E.
通讯作者：
Coleman, Robert E.