CD109 and squamous cell carcinoma.

CD109 and squamous cell carcinoma.
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CD109 和鳞状细胞癌。

DOI:
10.1186/s12967-018-1461-3
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发表时间:
2018-04-06
影响因子:
7.4
通讯作者:
Liu J
Liu J
中科院分区:
医学2区
文献类型:
--
作者:
Qi R;Dong F;Liu Q;Murakumo Y;Liu J

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鳞状细胞癌(Squamous cell carcinoma,SCC)是一种转移率高、预后差的恶性肿瘤。CD109是糖基磷脂酰肌醇锚定的细胞表面糖蛋白。最近,CD109成为SCC的潜在生物标志物和治疗靶点。越来越多的研究表明,CD109在人多器官SCC中高表达,可能参与SCC的进展。本文综述了CD 109在SCC中的表达模式,并讨论了CD 109在SCC发病机制中作用的分子机制。
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein. Recently, CD109 emerges as a potential biomarker and a therapeutic target for SCCs. Accumulating studies have reported that CD109 is highly expressed in human SCCs of multiple organs, and may contribute to the progression of SCCs. In this review, we summarized the findings on expression pattern of CD109 in SCCs, and discussed the molecular mechanisms underlying the roles of CD109 in pathogenesis of SCCs.
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