Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice.
Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice.
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DOI：
10.18632/aging.204354
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发表时间：
2022-10-24
期刊：
影响因子：
5.2
通讯作者：
Blagosklonny, Mikhail, V
中科院分区：
文献类型：
--
作者：
Blagosklonny, Mikhail, V
三篇杰出的出版物成为挑衅性的头条新闻，证明了雷帕霉素的早期治疗，包括发育生长期间的治疗，延长了动物的寿命，证实了功能亢进理论的预测，该理论将衰老视为一个准程序（发育生长的意外延续）部分由mTOR驱动。尽管它们具有很高的理论重要性，但其中两项在小鼠、果蝇和水蚤中的研究的临床应用不能在人类中实施，因为这需要在出生时就开始生长迟缓。第三项研究表明，在果蝇成年早期用雷帕霉素进行短暂（约占果蝇总寿命的20%）治疗与终身治疗一样有效，而晚期治疗则无效。然而，先前在小鼠中的研究表明，短暂的晚年治疗非常有效。基于功能亢进理论，本文试图调和相互矛盾的结果，并提出延长人类寿命的最佳治疗策略。
Making provocative headlines, three outstanding publications demonstrated that early-life treatment with rapamycin, including treatments during developmental growth, extends lifespan in animals, confirming predictions of hyperfunction theory, which views aging as a quasi-program (an unintended continuation of developmental growth) driven in part by mTOR. Despite their high theoretical importance, clinical applications of two of these studies in mice, Drosophila and Daphnia cannot be implemented in humans because that would require growth retardation started at birth. A third study demonstrated that a transient (around 20% of total lifespan in Drosophila) treatment with rapamycin early in Drosophila adult life is as effective as lifelong treatment, whereas a late-life treatment is not effective. However, previous studies in mice demonstrated that a transient late-life treatment is highly effective. Based on hyperfunction theory, this article attempts to reconcile conflicting results and suggests the optimal treatment strategy to extend human lifespan.
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DOI：
10.18632/aging.202674
发表时间：
2021-02-12
期刊：
Aging
影响因子：
--
作者：
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通讯作者：
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影响因子：
16.6
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影响因子：
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DOI：
10.18632/aging.100525
发表时间：
2012-12
期刊：
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影响因子：
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作者：
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影响因子：
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