Plasma Galanin is a Biomarker for Severity of Major Depressive Disorder
Plasma Galanin is a Biomarker for Severity of Major Depressive Disorder
复制标题
血浆甘丙肽是重度抑郁症严重程度的生物标志物
DOI：
10.2190/pm.48.2.d
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Xu ZQD
中科院分区：
文献类型：
--
作者：
Li H;Liu PZ;Wang CY;Xu ZQD
目的探讨血浆甘丙素水平与抑郁症严重程度的关系。方法采用汉密尔顿抑郁量表对79例重度抑郁症患者(女性52例，男性27例，发作期71例，缓解期8例)的抑郁症状严重程度进行评定。采集79例MDD患者、35例健康同胞和19例健康对照的空腹静脉血5毫升，制备血浆样本。结果MDD患者血浆甘丙素水平显著高于缓解期患者、健康同胞组和健康对照组(P<0.924)，而健康同胞组与健康对照组之间差异无统计学意义(P=0.05)。缓解组血浆甘丙素水平也显著高于健康对照组(P<；0.05)。在79例患者中，年龄与甘丙素水平无显著相关性(r=0.053，P=0.646)，按性别分层后，年龄与甘丙素水平也无相关性(P>；0.05)。女性患者血浆甘丙素水平与抑郁症严重程度呈显著正相关(r=0.329，df=42，P=0.020)，而男性患者无相关性。结论血浆甘丙素水平可能是反映抑郁症严重程度的重要生物学指标，尤其是女性患者。
ObjectiveThis study investigated the association between plasma galanin level and depression severity.MethodsThe severity of depression symptoms of 79 patients with major depressive disorder (MDD; 52 women and 27 men, 71 patients in onset, 8 in remission) was assessed using the 17-item Hamilton Depression Rating Scale. Venous fasting blood samples (5 mL) were taken from the 79 MDD patients, 35 healthy siblings, and 19 healthy controls, and plasma samples were prepared. Galanin levels in the plasma were measured by radioimmunoassay.ResultsPlasma galanin in MDD patients was significantly higher than that of remission patients, healthy siblings, or healthy controls (P< 0.05) There was no significant difference between the healthy sibling and healthy control groups (P= 0.924). Plasma galanin of remission patients was also significantly higher than that of healthy controls (P< 0.05). There was no significant correlation between age and galanin levels in the 79 patients (r= 0.053,P= 0.646), nor was there a correlation between age and galanin levels when patients were stratified by gender (P> 0.05). There was a significant positive correlation between plasma galanin levels and depression severity in women MDD patients (r= 0.329,df= 42,P= 0.020), but not in men patients.ConclusionsPlasma galanin levels may be an important biomarker for depression severity, especially in female patients.
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影响因子：
2.5
作者：
Yoshitake, T;Reenilä, K;Kehr, J
通讯作者：
Kehr, J
DOI：
10.1007/978-3-7091-0715-7_3
发表时间：
2014
期刊：
--
影响因子：
--
作者：
Donatella Marazziti;Grazia Rutigliano;S. Baroni;Liliana Dell'Osso
通讯作者：
Donatella Marazziti;Grazia Rutigliano;S. Baroni;Liliana Dell'Osso
影响因子：
3.2
作者：
Bromberger JT;Kravitz HM
通讯作者：
Kravitz HM
影响因子：
2.3
作者：
C. Benjet;L. Casanova;G. Borges;M. Medina-Mora
通讯作者：
C. Benjet;L. Casanova;G. Borges;M. Medina-Mora
影响因子：
3.2
作者：
Y. Uenoyama;H. Tsukamura;M. Kinoshita;S. Yamada;K. Iwata;V. Pheng;S. Sajapitak;M. Sakakibara;T. Ohtaki;H. Matsumoto;K. Maeda
通讯作者：
Y. Uenoyama;H. Tsukamura;M. Kinoshita;S. Yamada;K. Iwata;V. Pheng;S. Sajapitak;M. Sakakibara;T. Ohtaki;H. Matsumoto;K. Maeda