SVMHC: a server for prediction of MHC-binding peptides.
SVMHC: a server for prediction of MHC-binding peptides.
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SVMHC:用于预测MHC结合肽的服务器。
DOI:
10.1093/nar/gkl284
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发表时间:
2006-07-01
影响因子:
14.9
通讯作者:
Kohlbacher O
中科院分区:
文献类型:
--
作者:
Dönnes P;Kohlbacher O
Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based peptide vaccines. During the past decade a number of computational approaches have been introduced for the prediction of MHC-binding peptides, efficiently reducing the number of candidate binders that need to be experimentally verified. Here the SVMHC server for prediction of both MHC class I and class II binding peptides is presented. SVMHC offers fast analysis of a wide range of alleles and prediction results are given in several comprehensive formats. The server can be used to find the most likely binders in a protein sequence and to investigate the effects of single nucleotide polymorphisms in terms of MHC-peptide binding. The SVMHC server is accessible at .
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