SVMHC: a server for prediction of MHC-binding peptides.

SVMHC: a server for prediction of MHC-binding peptides.
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SVMHC:用于预测MHC结合肽的服务器。

DOI:
10.1093/nar/gkl284
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发表时间:
2006-07-01
影响因子:
14.9
通讯作者:
Kohlbacher O
Kohlbacher O
中科院分区:
生物学2区
文献类型:
--
作者:
Dönnes P;Kohlbacher O

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MHC结合多肽的鉴定是合理设计T细胞多肽疫苗的前提。在过去的十年里,已经引入了许多计算方法来预测MHC结合多肽,有效地减少了需要实验验证的候选结合蛋白的数量。本文介绍了用于预测MHC I类和II类结合多肽的SVMHC服务器。SVMHC提供了对广泛等位基因的快速分析,并以几种综合格式给出了预测结果。该服务器可用于寻找蛋白质序列中最可能的结合子,并研究单核苷酸多态对MHC-肽结合的影响。SVMHC服务器可通过访问。
Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based peptide vaccines. During the past decade a number of computational approaches have been introduced for the prediction of MHC-binding peptides, efficiently reducing the number of candidate binders that need to be experimentally verified. Here the SVMHC server for prediction of both MHC class I and class II binding peptides is presented. SVMHC offers fast analysis of a wide range of alleles and prediction results are given in several comprehensive formats. The server can be used to find the most likely binders in a protein sequence and to investigate the effects of single nucleotide polymorphisms in terms of MHC-peptide binding. The SVMHC server is accessible at .
DOI: 10.1038/nature01200
发表时间: 2002-11-28
期刊: NATURE
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