Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.
Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.
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DOI：
10.1371/journal.pone.0088150
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Takehara K
中科院分区：
文献类型：
--
作者：
Hasegawa M;Asano Y;Endo H;Fujimoto M;Goto D;Ihn H;Inoue K;Ishikawa O;Kawaguchi Y;Kuwana M;Ogawa F;Takahashi H;Tanaka S;Sato S;Takehara K
评估循环粘附分子水平作为系统性硬化症（SSc）早发性疾病患者疾病进展的预后指标的效用。在一项多中心、观察性研究中登记了92例表现为弥漫性皮肤硬化和/或间质性肺病的早发性SSc日本患者。采用酶联免疫吸附试验（ELISA）测定所有患者血清样本中细胞间粘附分子（ICAM）-1、E-选择素、L-选择素和P-选择素的浓度。在39名患者中，每年测量粘附分子水平，持续4年。对基线粘附分子水平预测随后临床和实验室特征进展和严重程度的能力进行了统计学评价。与健康对照组相比，SSc患者首次就诊时血清ICAM-1、E-选择素、P-选择素水平显著升高，血清L-选择素水平显著降低。总体而言，单因素分析显示，各时间点的血清ICAM-1水平与同一时间和随后年份的%肺活量（VC）呈显著负相关。多元回归分析显示，初始血清ICAM-1水平与第4年的%VC呈显著负相关。多元回归分析显示，第4年时血清P-选择素水平与健康评估问卷残疾指数（HAQ-DI）显著相关。初始粘附分子水平与其他临床特征（包括皮肤厚度评分）无显著相关性。基线粘附分子水平与随后的临床参数变化率无显著相关性。在SSc患者中，血清ICAM-1和P-选择素水平可分别作为呼吸功能障碍和身体残疾的预后指标。需要对更大人群进行进一步的纵向研究来证实这些发现。
To assess the utility of circulating adhesion molecule levels as a prognostic indicator of disease progression in systemic sclerosis (SSc) patients with early onset disease. Ninety-two Japanese patients with early onset SSc presenting with diffuse skin sclerosis and/or interstitial lung disease were registered in a multicentre, observational study. Concentrations of intercellular adhesion molecule (ICAM) −1, E-selectin, L-selectin, and P-selectin in serum samples from all patients were measured by enzyme-linked immunosorbent asssay (ELISA). In 39 patients, adhesion molecule levels were measured each year for four years. The ability of baseline adhesion molecule levels to predict subsequent progression and severity in clinical and laboratory features were evaluated statistically. At their first visit, serum levels of ICAM-1, E-selection, P-selectin were significantly elevated and serum L-selectin levels were significantly reduced in patients with SSc compared with healthy controls. Overall, serum ICAM-1 levels at each time point were significantly inversely associated with the %vital capacity (VC) of the same time and subsequent years by univariate analysis. The initial serum ICAM-1 levels were significantly inversely associated with the %VC at the fourth year by multiple regression analysis. The initial serum P-selectin levels were significantly associated with the health assessment questionnaire disability index (HAQ-DI) at the fourth year by multiple regression analysis. Initial adhesion molecule levels were not significantly associated with other clinical features including skin thickness score. Baseline adhesion molecule levels were not significantly associated with subsequent rate of change of clinical parameters. In patients with SSc, serum levels of ICAM-1 and P-selectin may serve as prognostic indicators of respiratory dysfunction and physical disability, respectively. Further longitudinal studies of larger populations are needed to confirm these findings.
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影响因子：
3.7
作者：
Ates, A;Kinikli, G;Duman, M
通讯作者：
Duman, M
影响因子：
27.4
作者：
Hou, Y.;Rabquer, B. J.;Koch, A. E.
通讯作者：
Koch, A. E.
影响因子：
15.3
作者：
Borges, E;Tietz, W;Vestweber, D
通讯作者：
Vestweber, D
DOI：
10.1038/nrrheum.2011.149
发表时间：
2011-10-25
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6
作者：
Hsu, Eileen;Feghali-Bostwick, Carol A.
通讯作者：
Feghali-Bostwick, Carol A.