Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene
Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene
复制标题
日本老年人原发性高血压与血管紧张素转换酶（ACE）基因I/D多态性的关系
DOI：
--
复制
发表时间：
2000
影响因子：
3.5
通讯作者：
S. Umemura
中科院分区：
文献类型：
--
作者：
Keiko Yoshida;T. Ishigami;I. Nakazawa;Akiko Ohno;K. Tamura;M. Fukuoka;S. Mizushima;S. Umemura
血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与心肌梗死及相关心血管疾病的发生有关。我们调查了ACE多态性与原发性高血压的可能关联，共263例/对照组，来自日本老年人（年龄在70岁以上）和中年人（年龄在30岁至60岁之间）。老年组高血压患者I/I纯合子频率显著高于对照组（33/57 vs 16/46; P = 0.02），但中年组无相关性（25/75 vs 26/85; P = 0.71）。类似地，在老年组中，至少有一个插入等位基因与原发性高血压相关（83/114 vs 46/92对照组; P = 0.001），但在中年组中不相关（78/150 vs 94/170; P = 0.524）。这些数据表明，ACE基因座的遗传变异可能与老年人血压的一些决定因素有关，并暗示ACE插入/缺失多态性参与日本人群中与年龄相关的原发性高血压的病因。
AbstractRecent evidence suggests that an insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) is associated with myocardial infarction and related cardiovascular diseases. We investigated a possible association of the ACE polymorphism with essential hypertension in a total of 263 cases/controls from among the elderly (age, over 70 years) and middle-aged (age between 30 and 60 years) Japanese population. The frequency of the I/I homozygote was significantly higher in hypertensive subjects than in controls in the elderly age group (33/57 vs 16/46; P = 0.02), but no association was observed in the middle-aged group (25/75 vs 26/85; P = 0.71). Similarly, having at least one insertion allele was associated with essential hypertension in the elderly age group (83/114 vs 46/92 in controls; P = 0.001), but not in the middle-aged group (78/150 vs 94/170; P = 0.524). These data suggest that genetic variation at the ACE locus may be associated with some determinants for blood pressure in elderly persons, and imply the involvement of the ACE insertion/deletion polymorphism in the etiology of age-related essential hypertension in the Japanese population.
影响因子：
37.8
作者：
O'Donnell, CJ;Lindpaintner, K;Levy, D
通讯作者：
Levy, D
ACE I/D 多态性与血压的背景依赖性关联。
DOI：
10.1161/01.hyp.34.4.773
发表时间：
1999
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Turner,ST;Boerwinkle,E;Sing,CF
通讯作者：
Sing,CF